Translational Research Core

转化研究核心旨在促进和促进皮肤领域的人类受试者研究 生物学和皮肤病。第一个目标是提供一个具有成本效益的中央资源， 志愿者参与人体体内研究和/或捐献血液或皮肤活检组织用于离体/体外研究 调查事务所核心执行程序，如皮肤暴露于模拟太阳辐射，半抗原 敏化和激发，非侵入性监测（例如，超声波检查，比色法，经表皮 水分损失测量）和组织采集（静脉穿刺、打孔和角膜刀活组织检查）。利用 这些职能的扩展主要是通过与转诊医生和 其他研究人员通过病例综合癌症中心，一般临床研究中心， 艾滋病研究中心和大学内的其他研究中心。一名研究助理负责协调 这些服务。第二个目标是提供新疗法临床试验的全面管理， 从实验室到床边，重点是提供最佳的翻译和临床数据。一 在一般试验设计以及数据和安全性监测方面具有专业知识的小组被召集起来， 指导或进行高质量的研究，通过与感兴趣的各种研究者的互动而产生， 皮肤研究此外，促进临床和实验室研究人员之间的互动， 阐明治疗作用机制和疾病病理机制的连续实验室研究。 第三个目标是促进青年研究人员和初级教员在人类学领域的职业发展， 基于主题的皮肤研究。这涉及在多个层面提供支持（例如，IRB提交、方案 设计、数据分析、手稿准备）。

The Translational Research Core is designed to promote and facilitate human subject research in skin biology and skin disease. The first aim is to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The Core performs procedures such as skin exposure to simulated solar radiation, hapten sensitization & elicitation, non-invasive monitoring (e.g., ultrasonography, chromometry, transepidermal water loss measurement) and tissue acquisition (venipuncture, punch & keratome biopsies). The utilization of these functions are expanded mainly by active interactions with physicians who refer patients and with other investigators through the Case Comprehensive Cancer Center, the General Clinical Research Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The second aim is to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design as well as data and safety monitoring are assembled to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The third aim is to foster career development of young investigators and junior faculty in the area of human subject-based skin research. This involves providing support at multiple levels (e.g. IRB submission, protocol design, data analysis, manuscript preparation) depending on investigator needs.