ASSESSMENT OF AGE-RELATED DIFFERENCES IN IN-VITRO CHOLINESTERASE INHIBITION I

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 本研究的目的是研究年轻健康成人和老年健康成人对一种称为胆碱酯酶抑制剂的药物的敏感性，如pryridostigmine（Mestinon），donepezil（Aricept）和galantamine（Razadyne）。 其中一些药物用于改善阿尔茨海默病患者的记忆功能和行为。 其他研究的结果表明，有些人可能比其他人对这些药物的影响更敏感;这项研究将确定年轻人是否比老年人对这些影响更敏感。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to study the sensitivity of young healthy adults and older healthy adults to a type of drug called cholinesterase inhibitors, such as pryridostigmine (Mestinon ), donepezil (Aricept ) and galantamine (Razadyne ). Some of these drugs are used to improve the memory function and behavior of patients with Alzheimer's Disease. Results from other studies suggest that some people may be more sensitive to the effects of these drugs than others; this research will be to determine if young adults may be more sensitive to the effects than older adults.