ETHNIC DIFFERENCES IN ACUTE PAIN AND ANALGESIC RESPONSE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将使用一个常见的急性临床疼痛模型来识别和表征导致种族群体在疼痛感知和止痛方面存在差异的心理、生理和遗传因素。目的1将确定种族群体对急性术后疼痛的知觉和生理反应的差异，并研究这些差异与遗传、术前心理物理和心理社会因素的关系。目的2将确定阿片类药物止痛和副作用的种族差异，并将检查解释组间止痛反应差异的遗传、药代动力学、药效学和心理社会因素。300名年龄在18岁之间的少数民族和白人患者将接受第三磨牙拔除手术。将评估术前实验性疼痛反应和心理社会措施，以及术后疼痛水平和药代动力学；将监测阿片类芬太尼的药效学反应。还将评估两组在术后即刻、术后数小时和术后最多3天的疼痛和止痛反应方面的差异。这项研究的长期目标是制定一系列计划研究，旨在阐明生物、心理和社会因素对疼痛种族差异的影响，并最终参与转化性研究，通过开发旨在提高疼痛患者生活质量的干预措施，减少临床疼痛的健康差距。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will use a common acute clinical pain model to identify and characterize psychosocial, physiological and genetic factors that contribute to ethnic group differences in pain perception and analgesia. Aim 1 will determine ethnic group differences in perceptual and physiological responses to acute post-operative pain and to examine how those are related to genetic, pre-operative psychophysical and psychosocial factors. Aim 2 will determine ethnic differences in opioid analgesia and side effects and will examine genetic, pharmacokinetic, pharmacodynamic, and psychosocial factors that explain group differences in analgesic responses. 300 minority and white patients age range 18-who undergo third molar extraction will be included in this study. Preoperative experimental pain responses and psychosocial measures will be assessed and postoperative pain levels along with pharmacokinetic; and pharmacodynamic responses to the opioid fentanyl will be monitored. Group differences in post-operative pain as well as analgesic responses immediately and for several hours post-operatively and up to 3 days post-procedure will also be assessed. The long-term goal of this study is to develop a programmatic line of research designed to elucidate biopsychosocial contributions to ethnic differences in pain and to eventually engage in translational research to reduce health disparities in clinical pain through the development of interventions designed to enhance the quality of life of individuals with pain.