Infrastructure Improvements for the Sabana Seca Field Station of the Caribbean Pr

描述（由申请人提供）：38年来，加勒比灵长类动物研究中心（CPRC）一直通过为国家重要的研究计划提供高质量的恒河猴来支持高质量，富有成效的研究。在过去的8年里，CPRC为PHS和nih赞助的生物医学研究项目提供了1300多只猴子，支持超过1.42亿美元的联邦拨款。其中7 600多万美元用于与艾滋病有关的倡议和疫苗研究。CPRC是全国第二大SPF殖民地，也是艾滋病相关研究项目中最大的SPF恒河猴提供者之一。为了保持高质量的动物护理标准并遵守监管机构的规定，CPRC需要对Sabana Seca野外站基础设施支持设施的关键要素进行翻新。这项申请的资金将用于以下方面：1)升级电力基础设施，2)翻新主要深水井，以及3)翻新动物围栏。我们预计对非人类灵长类动物测试新开发的治疗方法和疫苗的需求将会增加，我们担心缺乏足够的基础设施可能会阻碍CPRC动物护理计划和研究计划的发展。建议的改进将提高恒河猴的繁殖操作，这将导致群体繁殖产量的增加。这将反过来确保向美国国立卫生研究院资助的研究人员和机构提供更多具有明确病毒学和遗传状况的印度恒河猴。

DESCRIPTION (provided by applicant): For 38 years the Caribbean Primate Research Center (CPRC) has been supporting high-quality, productive research by providing high-quality rhesus macaques for research initiatives of National importance. During the past 8 years, the CPRC provided over 1,300 monkeys to PHS and NIH-sponsored biomedical research programs supporting over $142 million in federal grants. Over $76 million of this amount was for AIDS-related and vaccine research initiatives. The CPRC is the second largest SPF colony in the Nation, and one of the largest SPF rhesus macaque providers for AIDS related research projects. In order to maintain quality animal care standards and comply with regulatory agencies, the CPRC needs to renovate critical elements of the infrastructure support facilities at the Sabana Seca Field Station. Funds from this application will be used for the following: 1) upgrade of the electrical infrastructure, 2) renovation of the primary deep-water well and 3) renovation of animal enclosures. We foresee the increased need for non-human primates for testing newly developed therapeutics and vaccines, and our concern is that the lack of an adequate infrastructure could prevent the development of the animal care program and research initiatives at the CPRC. The proposed improvements will enhance the rhesus monkey breeding operation and this will result in an increase of the reproductive output of the colony. This will in turn assure that more Indian-origin rhesus macaques of defined virological and genetic status are made available to NIH-funded researchers and institutions.