Imaging Core

核心： 成像采集和分析核心是为了满足几个国家日益增长的需求而建立的。 研究人员对一系列物种进行高分辨率CT图像采集和分析。由于我们 发表的第一次使用HRCT评估气道反应性的狗，我们已经发表了几个 随后的研究，使用HRCT测量犬、羊和犬的气道壁和气道大小变化， 人类由于发展的需要，我们聘请了Masaru石井博士来扩大成像采集， 分析核心单元，包括磁共振成像，特别是超极化氦（3 He）成像 采集和分析。成像核心的实力已经通过我们获取 用于气道和实质定量分析的高度可重复的肺部图像。常规 肺功能测量不能评估气道硬度或减小的最大气道尺寸， 如通过随着肺膨胀的气道尺寸的变化所测量的。HRCT是一种直接的、无创的、放射性的 一种能够准确可靠地测量人体气道腔面积和气道壁厚度技术 体内气道。使用HRCT，可以重复气道腔和气道壁厚度 在体内不同肺体积下的多个气道的测量。在建议的工作中，我们将使用HRCT 重复测量不同肺容量下的气道大小、多个气道中的气道壁厚度 (2nd至第8代气道）和肺实质！COPD受试者中的密度作为气道指标 重塑此外，建立一个一致的气道图像数据库将有助于 与COPD进展相关的项目。HRCT也被证明是一种精确的工具， 通过测量肺实质来量化肺气肿！密度的为了增加 由于这种治疗和有害暴露测量的敏感性，我们计划评估肺部区域， 低破坏指数作为COPD进展的指标。核心项目将支持项目2和项目5， 与Core C交互。

CORES: The imaging acquisition and analysis core was established in response to the growing need of several investigators for High-resolution CT image acquisition and analysis across a range of species. Since our publication of the first use of HRCT to assess airway reactivity in dogs, we have published several subsequent studies, using HRCT to measure airway walls and airway size changes in dogs, in sheep, and in humans. Due to developing needs, we have hired Dr. Masaru Ishii to expanding the imaging acquisition and analysis core unit to include Magnetic Resonance imaging, specifically hyperpolarized helium (3He) imaging acquisition and analysis. The strength of the imaging core has been demonstrated by our ability to acquire highly reproducible lung images for quantitative analysis of airways and parenchyma. Conventional pulmonary function measurements are unable to assess airway stiffness or reduced maximum airway size, as measured by changes in airway size with lung inflation. HRCT is a direct, noninvasive, radiological technique that can accurately and reliably measure airway luminal area and airway wall thickness in human airways in vivo. Using HRCT, one can make repeated airway luminal and airway wall thickness measurements of multiple airways at different lung volumes in vivo. In the proposed work, we will use HRCT to make repeated measures of airway size at various lung volumes, airway wall thickness in multiple airways (2nd to 8th generation airways), and lung parenchyma! density in subjects with COPD as an index of airway remodeling. Furthermore, the development of a consistent database of airway images will be instrumental in linking projects related to progression of COPD. HRCT also has been demonstrated to be a precise tool for the quantification of emphysema by measurement of lung parenchyma! density. In order to increase the sensitivity of this measurement of treatment and harmful exposures, we plan to evaluate regions of lung with low destructive index as a measure of COPD progression. The Core will support Projects 2 and 5 and will interact with Core C.