Examining the Obesity Epidemic through Youth, Family, and Young Adults

描述(由申请人提供)： 该中心提案的目的是在青年、家庭和年轻人中进行关于肥胖和癌症的跨学科研究、培训和推广。拟建的中心将解决有关青少年和家庭肥胖的病因、预防和治疗的问题，并探索可能将肥胖与癌症联系起来的生物学途径。该中心的提案包括三个具体的研究项目。项目1是一项多因素、横断面和前瞻性的观察性研究，考察青少年肥胖发展的预测因素，包括社会文化因素、家庭因素、环境因素和个人因素。项目2是一项评估以家庭为基础的体重增加预防干预措施的研究，特别强调对导致体重增加的环境因素的干预。项目3是关于运动对年轻女性雌激素代谢、氧化应激和DNA修复机制的影响的研究。R01的三项赠款将由一个核心、一个数据服务和分析核心提供支持。该提案还包括职业发展部分、为发展项目提供大量资金以及传播/翻译部分。总体目标是推进跨学科科学，促进对肥胖、青年、家庭和癌症的了解；支持该领域新研究人员的职业发展；向更广泛的受众传播关于这一主题的科学知识。

DESCRIPTION (provided by applicant): The purpose of this Center proposal is to conduct transdisciplinary research, training, and outreach on obesity and cancer in youth, family, and young adults. The proposed Center will address questions about the etiology, prevention, and treatment of obesity in youth and families, and explore biological pathways that may link obesity to cancer. The center proposal includes three specific research projects. Project 1 is a multifactorial, cross-sectional, and prospective observational study examining predictors of obesity development in adolescents, including sociocultural factors, family factors, environmental factors, and individual factors. Project 2 is a study evaluating family-base, weight-gain prevention intervention that particularly emphasizes intervention on environmental contributors to weight gain. Project 3 is a study of the effects of physical activity on estrogen metabolism, oxidative stress, and DNA repair mechanisms in young women. The three R01 grants will be supported by one core, a Data Services and Analysis Core. The proposal also includes a career development component, substantial funding for developmental projects, and a dissemination/translation component. The overall goals are to advance transdisciplinary science in the advancement of understanding of obesity, youth, family, and cancer; to support the career development of new investigators in the field; and to disseminate scientific knowledge about the topic to broader audiences.