Community-Level Influences on the Onset, Progression and Desistance of Adolescent

描述(申请人提供)：候选人Jasmina Burdzovic Andreas博士正在通过辅导职业发展奖(K01)寻求5年的支持，以(1)增进她对青少年药物使用和滥用的了解，(2)发展和扩大与青少年人口中药物使用障碍的病因学和流行病学相关的风险和保护因素的独立纵向研究，以及(3)获得应用于精神疾病研究的生物统计学和流行病学方面的更多专业知识。拟议的奖项将为候选人提供必要的培训、指导和研究时间，以成功过渡到流行病学和人群心理健康的新领域，并掌握相关的研究方法。具体地说，Burdzovic Andreas博士的目标是加强她在发展精神病理学方面的现有培训和她在纵向数据方面的方法论经验，以包括研究处于危险中的青少年人口的流行病学方法，主要侧重于药物使用和滥用问题。因此，拟议的K01将使Burdzovic Andreas博士能够完全整合她在发展精神病理学方面的背景。她现有的统计知识，以及她对风险和复原力过程的持续研究兴趣，以及她成为一名关注青少年药物使用问题流行病学和病因学的独立调查员的长期职业目标。候选人将有效地利用她的家乡机构部门(布朗大学社区卫生部门)及其多个研究中心的跨学科性质。她将与全国公认的专家团队密切合作，包括斯蒂芬·布卡博士(主要导师)以及约瑟夫·霍根博士、克里斯蒂娜·杰克逊博士和罗纳德·塞弗博士(共同导师)，他们将在她的培训、研究和职业发展目标方面为她提供支持。这些目标将通过以下方式实现：(1)在物质使用和滥用研究方面进行更多的培训；(2)制定一条关于青少年物质使用的独立研究路线，其中包括查明和检查社区一级与以前有过这种行为的青少年自然停止和停止使用药物(即烟草、酒精和大麻)有关的因素；以及(3)在先进的生物统计学、纵向和流行病学研究方法方面获得进一步的专门知识。拟议的研究构成部分将利用两个现有的具有社区代表性的纵向数据集中关于青少年的数据：(1)斯普林菲尔德儿童发展项目(SCDP，N=357；年龄范围：12-18)和(2)芝加哥社区人类发展项目(PHDCN，N=2,976；年龄范围：9-24)。这两个数据集一起，将允许检查青少年药物使用和滥用的不同纵向概况，以及确定与这些问题的自然减少相关的更广泛生态因素的独特星座--最终为预防和治疗工作提供信息。

DESCRIPTION (provided by applicant): The candidate, Dr. Jasmina Burdzovic Andreas, is seeking 5 years of support though the Mentored Career Development Award (K01) in order to (1) advance her understanding of adolescent substance use and abuse, (2) develop and expand an independent line of longitudinal research on risk and protective factors pertinent to etiology and epidemiology of substance use disorders among adolescent populations, and to (3) gain additional expertise in biostatistics and epidemiology as applied to the study of psychiatric disorders. The proposed award will provide the candidate with the training, mentoring, and research time necessary for the successful transition into the new fields of epidemiology and population mental health, and for the mastery of the relevant research methods. Specifically, Dr. Burdzovic Andreas aims to augment her existing training in developmental psychopathology and her methodologipal experience with longitudinal data to include epidemiologic approaches to the study of adolescent populations at risk, focusing primarily on substance use and abuse issues. Thus, the proposed K01 will allow Dr. Burdzovic Andreas to fully integrate her background in developmental psychopathology. Her existing statistical knowledge, and her continued research interest in the processes of risk and resilience with her long-term career goals of becoming an independent investigator concerned with epidemiology and etiology of adolescent substance use problems. The candidate will effectively take advantage of the interdisciplinary nature of her home institution department (Brown University, Department of Community Health) and its multiple research centers. She will work closely with a team of nationally recognized experts -- including Dr. Stephen Buka (primary mentor) and Drs. Joseph Hogan, Kristina Jackson, and Ronald Seifer (co-mentors) - who will support her in her training, research, and career development objectives. These objectives will be achieved though (1) additional training in substance use and misuse research, (2) the development of an independent line of research on adolescent substance use, which includes identifying and examining community-level factors associated with naturally-occurring desistence and cessation in substance use (i.e., tobacco, alcohol, and marijuana) among adolescents who had previously engaged in such behaviors, and (3) acquisition of further expertise in advanced biostatistics, longitudinal and epidemiologic research methods. The proposed research component will utilize data on adolescents from two existing longitudinal and community-representative data sets: (1) Springfield Child Development Project (SCDP, N = 357; Age range: 12-18) and (2) Project on Human Development in Chicago Neighborhoods (PHDCN, N = 2,976; Age range: 9-24). Together, these two data sets will allow for examination of different longitudinal profiles of adolescent substance use and abuse, as well as of identification of unique constellations of broader ecological factors associated with naturally occurring reductions in these problems - ultimately informing prevention and treatment efforts.