EXPLORATORY CENTER FOR VACCINOLOGY RESEARCH (RMI)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 疫苗学跨学科研究探索中心（ECIRVE）致力于疫苗研究。埃默里大学吸引或培养了基础疫苗科学（免疫学和分子发病机制）、疫苗开发、疫苗试验、疫苗建模、疫苗流行病学和疫苗政策领域的国家领导者。 该中心创建了一个由国家领导人和中心主任组成的多学科科学工作理事会，以制定解决疫苗学问题的新策略。我们探讨了如何整合新的定量方法（基因组学，蛋白质组学，系统生物学和其他计算方法）评估疫苗的免疫反应和反应原性，开发更好的动态方法建模的疫苗使用，并计划综合模型的疫苗的经济评估。 此外，我们还探讨了定量方法的设计和局限性，以确定对流感疫苗的适应性和先天免疫应答的分子特征，并设计流感疫苗政策的新方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Exploratory Center for Indisciplinary Research in Vaccinology (ECIRVE) is a commitment to vaccine research. Emory University has attracted or developed national leaders in basic vaccine sciences (immunology and molecular pathogenesis), vaccine development, vaccine trials, vaccine modeling, vaccine epidemiology and vaccine policy. The Center created a multidisciplinary scientific working council of national leaders and center directors to develop novel strategies for problem-solving in vaccinology. We explored how to integrate new quantitative methodologies (genomics, proteomics, systems biology, and other computational methodologies) for assessment of vaccine immune responses and reactogenicity, develop better dynamic methods for modeling of vaccine use, and plan integrative models for economic assessment of vaccines. Additionally, we explored the design and limitations of quantitative methodologies to define molecular signatures of adaptive and innate immune responses to influenza vaccines, and to design novel approaches to influenza vaccine policy.