PILOT OF GREEN TEA FOR WEIGHT LOSS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 绿茶提取物无需处方即可获得，并作为膳食补充剂出售。它没有被批准用于预防或治疗任何疾病，也从未被食品和药物管理局评估过用于减肥或治疗肥胖症。此前对人体的研究表明，绿茶提取物可能有助于超重的人减肥。绿茶在肥胖患者身上还没有被研究过。这项双盲随机研究的主要目的是评估在肥胖受试者中，在18周内服用绿茶提取物是否比服用安慰剂的减肥效果更好。研究人员还将研究绿茶提取物是否会影响身体成分和能量代谢。他们还将研究绿茶提取物是否可以改变血清甘油三酯和胆固醇的水平。这项研究的第二个目的是了解一种名为“儿茶酚-o-甲基转移酶”的基因的个体差异是否与减肥有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Green tea extract is available without a prescription and is sold as a dietary supplement. It is not approved to prevent or cure any disease and has never been evaluated by the Food and Drug Administration for weight loss or the treatment of obesity. Previous research studies in humans indicate that green tea extracts may help overweight people lose weight. Green tea has not been studied in patients who are obese. The main purpose of this double-blinded, randomized study is to evaluate whether taking a green tea extract results in more weight loss over 18 weeks than taking placebos in obese subjects. The investigators will also study whether green tea extract affects body composition and as energy metabolism. They will also study whether green tea extract can change the levels of serum triglycerides and cholesterol. A secondary purpose of the study is to see if individual differences in a gene called "catechol-o-methyl transferase" are related to weight loss.