MECHANISMS UNDERLYING DRUG-DIET INTERACTIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 类似于发表得很好的“西柚汁效应”，正在进行的研究正在评估其他饮食物质对药物处置的相互作用潜力。例如，GCRC 32354调查了小红莓汁对氟伐他汀代谢和红霉素呼气试验的影响；受试者登记和参与已经完成，数据已经评估。本研究旨在确定小红莓汁增强华法林抗凝作用的机制是否与其抑制华法林代谢有关。第二个目标是确定蔓越莓汁是否会引起与咪达唑仑类似的葡萄柚果汁相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Similiar to the well published "grapefruit juice effect", ongoing studies are evaluating the interaction potential of other dietary substances on drug disposition. For example, GCRC 32354 investigated the effect of cranberry juice on fluvastatin metabolism and on the erythromycin breath test; subject enrollment and participation has been completed and the data have been evaluated. This study proposed in the present application is designed to determine whether the mechanism underlying the enhancement of the anticoagulative effect of warfarin by cranberry juice is due to inhibition of varfarin metabolism by the juice. A secondary objective is to determine whether cranberry juice elicits a grapefruit juice-type interaction with midazolam.