CHAVI 012 - MUCOSAL AND INNATE IMMUNE RESPONSES AND VIRAL RESERVOIRS IN TISSUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：本研究旨在研究急性HIV-1感染过程中组织和细胞的粘膜免疫反应和先天免疫反应以及病毒库。 参与者：参与者将包括100名急性HIV-1感染者，约20名已确诊的HIV-1感染者，以及约30名未感染HIV的参与者。 程序(方法)：研究将从三组中的每一组中获取细胞，用于通过白细胞分离、内窥镜检查和骨抽吸物进行分析。并不是所有的三组都会接受所有的测试程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: This study is being done to study mucosal and innate immune responses and viral reservoirs in tissues and cells during Acute HIV-1 Infection. Participants: Participants will consist of 100 subjects with Acute HIV-1 infection, about 20 with established HIV-1 infection, and about 30 HIVuninfected participants. Procedures (methods): The study will obtain cells from each of the 3 groups for analysis by using leukapheresis, endoscopy, and bone aspirates. Not all 3 groups will undergo all testing procedures.