BIOMARKER PROFILES AS PREDICATORS OF NEONATAL SEPSIS AND RECOVERY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 败血症是新生儿重症监护病房常见且严重的问题，特别是在极低出生体重儿中。血培养诊断困难、耗时且缺乏敏感性。超过20%的极低出生体重婴儿经历一次或多次迟发性脓毒症发作，定义为3天后发生的任何脓毒症。迟发性脓毒症首次发作的中位年龄为17天。延迟治疗直到出现症状可能会危及生命。另一方面，在未感染的婴儿中反复使用抗菌药物治疗，通过促进耐药微生物的发展，对这些婴儿具有潜在风险。因此，这是一个理想的人口评价，以开发一种快速和敏感的产品，以确定感染。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight infants. Diagnosis by blood culture is difficult, time consuming, and lacks sensitivity. Over 20% of all very low birth weight infants experience one or more episodes of late onset sepsis defined as any sepsis occurring after 3 days of age. The median age for the first episode of late onset sepsis is 17 days. Delaying treatment until symptoms arise can be life threatening. On the other hand, recurrent treatment with antimicrobial agents in infants that are not infected holds potential risks to these infants by furthering the development of resistant organisms. This therefore, is an ideal population to evaluate to develop a rapid and sensitive product to identify infection.