DIABETES PREVENTION PROGRAM OUTCOMES STUDY (DPPOS)

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 DPPOS的主要目的是评价积极DPP干预对a）未来5-10年随访期间糖尿病和B）复合糖尿病相关微血管病变和心血管疾病结局发展的长期影响。正在测试的假设是，与之前的安慰剂组相比，持续的生活方式干预和二甲双胍将在糖尿病发展率方面提供持续的分离，并且DPP和DPPOS期间预防或延迟糖尿病将转化为复合结局的发生率降低和健康状况改善。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of the DPPOS is to evaluate the long-term effects of active DPP interventions on the development of a ) diabetes during a further 5-10 years of follow-up and b) composite diabetes-related microangiopathic and cardiovascular disease outcomes. The hypotheses being tested are that both the continued lifestyle intervention and metformin will provide continued separation in the rates of diabetes development, compared with the former placebo group, and that the prevention or delay of diabetes during the DPP and DPPOS will translate into reduced rates of composite outcomes and improved health status.