NEURAL RESPONSE TO ADVERTISING CUES IN ADOLESCENTS: A PILOT FMRI STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 尼古丁依赖被认为是吸烟成瘾行为的一个潜在因素（Chiamulera 2005）。来自成瘾理论的实验方法研究了非药物因素的影响，特别是与药物有关的刺激对吸毒行为的影响。成瘾理论认为环境线索是成瘾行为的可能诱因。线索反应基于这样一种假设，即与非吸毒者相比，吸毒者更容易对与毒品有关的刺激（如视觉、嗅觉、听觉、触觉等）作出反应（Chiamulera，2005年）。线索反应范式主要被理解为经典条件反射的影响（Carter和Tiffany 1999）。 对酒精、尼古丁和其他物质以及其他成瘾行为（如赌博）的成年人进行了线索反应性研究，结果显示与非使用者相比，心理、认知和神经影响不同（Carter和Tiffany 1999; Chiamulera 2005;乔治et al. 2001; McDermut和Haaga 1998;波滕扎et al. 2003）。在青少年中，使用功能性磁共振成像（fMRI）对患有酒精使用障碍（AUD）的受试者的线索反应进行了检查（Tapert et al. 2003）。青少年对环境刺激的线索反应的神经机制尚未完全了解，尤其是广告意象的影响。本研究的目的是利用功能磁共振成像技术分析青少年对香烟广告的神经反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nicotine dependence is believed to be an underlying factor in addictive smoking behavior (Chiamulera 2005). Experimental approaches derived from addiction theory have looked at the effect of non-pharmacological factors, specifically drug-related stimuli on drug-taking behavior. Environmental cues are often indicated in addiction theory as a possible reinforcer of addictive behavior. Cue reactivity is based on the hypothesis that drug users are predisposed to react to drug-related stimuli such as visual, olfactory, auditory, tactile, etc. versus non-drug users (Chiamulera 2005). The cue reactivity paradigm is primarily understood as an effect of classical conditioning (Carter and Tiffany 1999). Cue reactivity studies have been conducted on adults with alcohol, nicotine and other substances in addition to other addictive behaviors, such as gambling, and have shown differential psychological, cognitive and neural effects versus adults who are non-users (Carter and Tiffany 1999; Chiamulera 2005; George et al. 2001; McDermut and Haaga 1998; Potenza et al. 2003). In adolescents, cue reactivity has been examined using functional magnetic resonance imaging (fMRI) with subjects suffering from Alcohol Use Disorder (AUD) (Tapert et al. 2003). The neural mechanism underlying cue reactivity in response to environmental stimuli in adolescents is not fully understood, especially in regard to the effect of advertising imagery. The purpose of the current study is to use fMRI to analyze neural responses to cigarette advertising in adolescents.