CRANIOFACIAL FEATURES NORMATIVE DATABASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议开发一个标准化的数据库，其中包括150名没有被诊断为头面部疾病的人的3D图像。创建这一规范数据库的目的有两个。主要目的是描述无颅面疾患的儿童和年轻人的典型头面部特征。我们将通过测量人体尺寸和对3D图像进行形状分析来实现这一点。第二个目标是量化典型儿童和那些被诊断为头面部差异的儿童在头面部特征上的差异。我们将通过将标准数据与头面部差异儿童的测量结果进行比较来实现这一点。3D图像标准数据库的开发将建立在数据收集的基础上，这是我们在颅面研究中心进行的两项先前研究的一部分。我们目前建议收集的标准数据将立即对其中一项研究的继续有用，在这项研究中，我们将确定22q11.2缺失综合征患者受影响的头面部特征。更广泛地说，我们目前建议收集的标准数据将是一个宝贵的资源，将在未来用于研究各种颅面疾病中的颅面变异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to develop a normative database of 3D images from 150 individuals who have no diagnosed craniofacial disorders. The purpose of creating this normative database is two-fold. The primary aim is to characterize typical craniofacial features in children and young adults without craniofacial disorders. We will accomplish this by taking anthropometric measurements and performing shape analysis of the 3D images. The second aim is to quantify differences in craniofacial characteristics between typical children and those with diagnosed craniofacial differences. We will do this by comparing the normative data to measurements obtained in children with craniofacial differences. The development of a normative database of 3D images will build upon data collection begun as part of 2 prior studies that we have conducted in the craniofacial research center. The normative data we currently propose to collect will be immediately useful in a continuation of one of those studies, in which we will identify the craniofacial features affected in individuals with 22q11.2 deletion syndrome. More broadly, the normative data we currently propose to collect will be an invaluable resource to be used in the future for investigating craniofacial variation in a wide variety of craniofacial disorders.