SAGITTAL SYNOSTOSIS: 3D PHOTOGRAPHY PROJECT

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项试点研究正在进行，以确定最好的方法来表征头部形状的差异，观察到的个人与矢状缝早闭和他们的亲属。本研究中收集和分析的数据将被用作更大研究计划的初步数据，以确定矢状骨缝早闭的原因。 骨缝早闭导致舟状头畸形，一种狭长的头部形状，前额突出，枕骨狭窄隆起。在少数家庭中，其他亲属被诊断为矢状骨缝早闭。 一些家族报告家族成员有长窄头或大额头，但没有被诊断为矢状骨结合。 我们认为矢状骨结合是一个复杂的条件，由于遗传和环境因素。此时矢状骨缝的原因很大程度上无法解释。发展一个可重复的和准确的三维测量头的形状将是重要的，为未来的研究，以确定矢状骨缝的遗传原因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study is being done to determine the best method of characterizing head shape differences observed in individuals with sagittal synostosis and their relatives. Data collected and analyzed in this study will be used as preliminary data in a larger research proposal to identify causes of sagittal synostosis. Sagittal synostosis results in scaphocephaly, a long narrow head shape with a prominent forehead and narrow bulging occiput. In a few families, additional relatives have been diagnosed with sagittal synostosis. Some families have reported family members with long narrow heads or large foreheads, who have not been diagnosed with sagittal synostosis. We propose that sagittal synostosis is a complex condition due to genetic and environmental factors. At this time causes of sagittal synostosis are largely unexplained. Development of a reproducible and accurate three-dimensional measure of head shape will be important for future studies to identify genetic causes of sagittal synostosis.