IRON STORES, PERIODIC LEG MOVEMENTS, AND SLEEPINESS IN OBSTRUCTIVE SLEEP APNEA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 睡眠期间的周期性腿部运动（PLMS）是短暂的，重复的腿部抽搐，可能与睡眠中的觉醒和过度的白天嗜睡有关。PLMS和不宁腿综合征，这是一种以在清醒时发生的令人烦恼的腿部感觉和不安为特征的疾病，与铁水平低有关。以前的研究已经表明PLMS，不宁腿综合征和低身体铁储备之间的关系（铁是通过血液中铁蛋白的量间接测量的）。铁蛋白是一种在体内储存铁的蛋白质，血液中的铁蛋白水平与体内储存的铁量成正比。据认为，如果大脑中没有足够的铁，可能会发生不宁腿综合征和PLMS。这是因为铁是合成多巴胺所必需的，多巴胺是脑细胞的重要化学信使。多巴胺传递的问题被认为是不宁腿综合征和PLMS的原因，这两种情况都可以通过多巴胺治疗得到改善。多巴胺也被认为在嗜睡和警觉方面具有关键作用。PLMS常见于许多其他睡眠中断病症，例如阻塞性睡眠呼吸暂停（OSA），其特征在于反复发生完全或部分气道阻塞事件，伴有相关的觉醒和氧饱和度下降。过度嗜睡是OSA患者的常见症状。PLMS在过度嗜睡疾病中的高频率增加了低水平铁可能在OSA中发挥作用的可能性。因此，本研究的主要目的是确定OSA患者铁蛋白水平（从血液样本中获得）、PLMS和日间嗜睡之间的关系。具体目的是：1）确定80例疑似OSA患者的铁蛋白水平; 2）确定铁蛋白水平与PLMS之间的相关性; 3）确定OSA患者铁蛋白水平与日间嗜睡之间的相关性。这项研究的结果可以提供重要的信息，这将有助于了解缺铁在其他睡眠障碍中的作用，除了RLS和PLMS。'

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic leg movements during sleep (PLMS) are brief, repeated leg jerks that may be associated with arousals from sleep and excessive daytime sleepiness. PLMS and restless legs syndrome, which is a disorder characterized by bothersome leg sensations and restlessness that happen during wake, are associated with low levels of iron. Previous studies have shown a relationship between PLMS, restless legs syndrome, and low body iron stores (iron was measured indirectly by the amount of ferritin in the blood). Ferritin is a protein that stores iron in the body and the ferritin level in blood is proportional to the amount of iron stored in the body. It is thought that if there is not enough iron in the brain, restless legs syndrome and PLMS may occur. This is because iron is required for the synthesis of dopamine, an important chemical messenger for brain cells. Problems with dopamine transmission is believed to be a cause of restless legs syndrome and PLMS and both conditions improve with dopamine therapy. Dopamine is also believed to have a critical function in sleepiness and alertness. PLMS is common in many other sleep-disrupting conditions, such as obstructive sleep apnea (OSA), a condition characterized by repeated events of full or partial airway obstruction with associated arousals and oxygen desaturation. Excessive sleepiness is a common complaint in patients with OSA. The high frequency of PLMS in disorders of excessive sleepiness raises the possibility that low levels of iron may play a role in OSA. The main aim of this study, therefore, is to determine the relationship between ferritin levels (obtained from a blood sample), PLMS, and daytime sleepiness in patients with OSA. The specific aims are 1) to determine ferritin levels in 80 patients that have suspected OSA; 2) to determine the association between ferritin levels and PLMS; and 3) to determine the association between ferritin levels and daytime sleepiness in patients with OSA. This The results of this study could provide important imformation that will help to understand the role of iron deficiency in other sleep disorders besides RLS and PLMS.'