GLUTATHIONE REPLACEMENT IN CHRONIC ALCOHOL ABUSE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究拟验证以下假设：1）有慢性酒精滥用史的健康个体，其肺泡-毛细血管屏障功能改变与肺GSH浓度降低相关。2)慢性酒精滥用史与ARDS重症患者肺泡毛细血管通透性更严重的缺陷相关。3)GSH缺乏是慢性酒精滥用史患者和有酒精滥用史的ARDS患者中肺泡-毛细血管屏障功能异常的原因，口服GSH替代疗法将纠正这种异常。如果这些假设能够得到证实，GSH替代治疗作为酒精中毒患者急性肺损伤的预防和治疗酒精中毒患者的急性呼吸窘迫综合征（ARDS）就可以得到验证。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes to test the following hypotheses: 1) Otherwise healthy individuals with a history of chronic alcohol abuse have altered alveolar-capillary barrier function associated with decreased pulmonary GSH concentrations. 2) A history of chronic alcohol abuse will be associated with more severe defects in alveolar-capillary permeability in critically ill patients with ARDS. 3) GSH deficiency is a cause of abnormal alveolar-capillary barrier function in both individuals with a history of chronic alcohol abuse and ARDS patients with a history of alcohol abuse, and oral GSH replacement therapy will correct the abnormality. If these hypotheses can be confirmed, GSH replacement as prophylaxis against acute lung injury in alcoholic patients at risk, and as therapy for alcoholic patients with ARDS can be tested.