High-Resolution In Vivo Ultrasound Imaging Using VisualSonics VEVO 2100 System

描述(由申请人提供)：通过S10 NIH资助机制申请资金，以购买Visualsonics Vevo 2100高分辨率小动物超声成像系统，由10个主要项目(代表6名研究人员，拥有12项NIH资助)和6个小项目共享。这16个项目中的每个项目都将从Vevo 2100的使用中产生增值效益。伊利诺伊大学不存在这样的共享能力，尽管许多开创性的超声成像发现可以追溯到伊利诺伊大学60多年的基础科学超声研究。然而，随着大学研究人员将他们的研究更接近于直接的临床活动，在高效、高通量和纵向研究条件下对小动物进行高频超声成像(定性和定量)需要所要求的系统类型。我们的提案概述了(1)科学需求；(2)技术支持、管理和监督；(3)具有代表性的研究员研究应用；(4)机构承诺；以及(5)我们建议的Visualsonics Vevo 2100系统对学术界的好处。Vevo 2100将由一个拥有成熟的超声波专业知识和动物研究(包括青蛙、小鼠、大鼠、兔子、猫)的团队管理，并得到大量机构的支持。一般相关性：我们建议的Visualsonics Vevo 2100系统为用户提供高分辨率的定性和定量超声成像能力，以便使用小动物模型更好地开发、表征和治疗人类疾病。 与公共健康相关：通过S10 NIH资助机制申请资金，以购买Visualsonics Vevo 2100高分辨率小动物超声成像系统，由10个主要项目(代表6名研究人员，他们拥有12笔NIH资助的赠款)和6个小型项目共享。伊利诺伊大学不存在这样的共享能力，尽管许多开创性的超声成像发现可以追溯到伊利诺伊大学60多年的基础科学超声研究。我们建议的Vevo 2100系统为用户提供高分辨率的定性和定量超声成像能力，以便使用小动物模型更好地开发、表征和治疗人类疾病。

DESCRIPTION (provided by applicant): Funds are requested via the S10 NIH funding mechanism to purchase a VisualSonics Vevo 2100 high-resolution small-animal ultrasound imaging system to be shared by 10 major projects (representing 6 investigators who have 12 NIH-funded grants) and 6 minor projects. Each of the 16 projects will yield value-added benefits from the use of the Vevo 2100. Such a shared capability does not exist at the University of Illinois although many of the seminal ultrasound imaging discoveries can be traced to the more than 60 years of basic science ultrasound research at the University of Illinois. However, as the University investigators transition their research closer to direct clinical activities, high- frequency ultrasound imaging (qualitative and quantitative) of small animals under efficient high- throughput and longitudinal study conditions require the type of system being requested. Our proposal outlines the (1) scientific need; (2) technical support, administration, oversight; (3) representative investigator research applications; (4) institutional commitment; and (5) academic community benefit of our proposed VisualSonics Vevo 2100 system. The Vevo 2100 will be managed by a team with established ultrasound expertise and animal-based studies (included herein: frog, mouse, rat, rabbit, cat) with substantial institutional support. General Relevance: Our proposed VisualSonics Vevo 2100 system provides users with high-resolution qualitative and quantitative ultrasound imaging capabilities in order to better develop, characterize, and treat human diseases using small animal models. PUBLIC HEALTH RELEVANCE: Funds are requested via the S10 NIH funding mechanism to purchase a VisualSonics Vevo 2100 high-resolution small-animal ultrasound imaging system to be shared by 10 major projects (representing 6 investigators who have 12 NIH-funded grants) and 6 minor projects. Such a shared capability does not exist at the University of Illinois although many of the seminal ultrasound imaging discoveries can be traced to the more than 60 years of basic science ultrasound research at the University of Illinois. Our proposed Vevo 2100 system provides users with high-resolution qualitative and quantitative ultrasound imaging capabilities in order to better develop, characterize, and treat human diseases using small animal models.