Musculoskeletal Research Training Program

描述(申请人提供)：罗切斯特梅奥诊所的肌肉骨骼研究人员致力于美国骨骼和关节十年的目标，并致力于减轻所有肌肉骨骼疾病患者的痛苦。NIAMS在1995-2000年间资助了整形外科132人的培训补助金，马克·博兰德博士担任主任。自上一次培训计划以来，该机构招募了几名新的研究人员，并促进了肌肉骨骼主题的发展，该主题专注于巩固这些新研究人员和现有教员的努力，他们是整形外科、流行病学、骨质疏松症以及骨和软骨生物学领域的领导者。拟议的培训方案将提供机会，在现有机构基础设施内支持未来肌肉骨骼研究人员的培训。拟议培训计划的目标是：(1)通过向下一代独立研究人员提供出色的研究和教育机会，延续梅奥诊所在肌肉骨骼研究培训方面的卓越和传统，他们将促进肌肉骨骼疾病的知识和治疗，并能够与基础科学和临床同事进行富有成效的互动，以及(2)为学生和博士后培养一个跨学科的教育环境，包括肌肉骨骼疾病、基础生物学、生物医学工程、生物力学和流行病学方面的培训。 这项肌肉骨骼研究的培训计划涉及梅奥诊所罗切斯特的14名培训教师，他们都有校外支持的研究计划。培训计划教员的研究优势集中在整形外科、生物力学和生物医学工程(Amadio、An、Bishop、Kaufman、O‘Driscoll、Yaszemski)、基于临床结果的研究、流行病学以及矫形和肌肉骨骼疾病的机械性临床调查研究(Amin、Gabriel、Kholsa、Leibson)和基础科学(Ekker、Kumar、Oursler、Westendorf)等领域。韦斯特多夫博士将担任该项目的负责人。她是一位经验丰富的导师和培训项目负责人。她将得到联合主任阿马迪奥博士和科斯拉博士的协助，他们都是临床科学家，有着出色的培训记录。 要求在五年内每年为8名实习生(4名博士后、2名博士后和2名短期博士后)提供支助。博士后研究员将由个人导师、培训项目广告和住院医生/研究员项目招聘。有资格参加该培训计划的博士前(博士)实习生将被梅奥研究生院录取。短期博士前学生将从梅奥医学院和美国其他完全认可的医学院招收。培训计划将通过研究研讨会、拨款撰写研讨会、期刊俱乐部和提出新数据的联合小组会议等计划加以整合和丰富。该计划的主要目标是吸引杰出的年轻医生和科学家进入肌肉骨骼研究领域，并帮助他们的智力和技术发展成为对肌肉骨骼疾病的机制和治疗感兴趣的多产和独立的研究人员。

DESCRIPTION (provided by applicant): Musculoskeletal researchers at Mayo Clinic Rochester are committed to the goals of the U.S. Bone and Joint Decade, and in alleviating the suffering of all those afflicted with musculoskeletal disorders. The NIAMS supported a 132 training grant in the Department of Orthopedic Surgery from 1995-2000, with Dr. Mark Bolander as the Director. Since this last training program, the institution has recruited several new investigators and fostered the development of a Musculoskeletal Theme, which is focused on consolidating the efforts of these new researchers and existing faculty who are leaders in the fields of orthopedics, epidemiology, osteoporosis, and bone and cartilage biology. The proposed training program will provide opportunities to support the training of future musculoskeletal researchers within the existing institutional infrastructure. The objectives of the proposed training program are to: (1) Continue Mayo Clinic's excellence and tradition in musculoskeletal research training by providing outstanding research and educational opportunities to the next generation of independent investigators who will advance knowledge and treatment of musculoskeletal diseases and who are capable of productive interactions with both basic science and clinical colleagues, and (2) Foster an interdisciplinary educational environment for students and postdoctoral fellows that includes training in musculoskeletal disease, basic biology, biomedical engineering, biomechanics and epidemiology. This training program in Musculoskeletal Research involves 14 training faculty at Mayo Clinic Rochester, all of whom have extramurally supported research programs. The research strengths of the training program faculty are in the areas of orthopedics, biomechanics and biomedical engineering (Amadio, An, Bishop, Kaufman, O'Driscoll, Yaszemski), clinical outcomes-based research, epidemiology, and mechanistic clinical-investigative studies for orthopedic and musculoskeletal disease (Amin, Gabriel, Kholsa, Leibson), and basic science (Ekker, Kumar, Oursler, Westendorf). Dr. Westendorf will server as director of the program. She is an experienced mentor and training program leader. She will be assisted by codirectors, Dr. Amadio and Dr. Khosla, who are clinician scientists with outstanding training records. Support is requested for eight trainees (4 postdoctoral, 2 predoctoral PhD students, and 2 short-term predoctoral students) each year for five years. Postdoctoral fellows will be recruited by individual mentors, training program advertisements, and the residency/fellowship programs. Predoctoral (PhD) trainees that will be eligible for this training program will be accepted into the Mayo Graduate School. Short-term predoctoral students will be recruited from the Mayo Medical School and other fully accredited medical schools in the United States. The training program will be integrated and enriched by a program of research seminars, grant writing workshops, journal clubs, and joint group meetings where new data are presented. The primary goals of the program are to attract exceptional young physicians and scientists into the field of musculoskeletal research and to assist their intellectual and technical development into productive and independent investigators interested in the mechanisms and treatment of musculoskeletal diseases.