Animals Models Core

这个骨髓孢子项目的主要目标是开发新的靶向疗法，以更有效地 治疗多发性骨髓瘤(MM)患者。临床上相关的动物模型对于检查血管内皮细胞 新药的体内功效。动物模型核心(D核心)的专用人员和设施 为该计划提供临床上相关的动物模型和动物研究方面的专业知识 实现项目目标。核心人员与孢子调查人员密切合作，规划动物 研究并开发最佳的和临床相关的骨髓瘤小鼠模型。在过去的5年里， 淋巴瘤和骨髓瘤科和安德森癌症中心提供了极好的 获得原发骨髓瘤样本的条件、骨髓瘤组织库、 临床和转化性研究计划以及动物设施，以提供独特的、与临床相关的 建立骨髓瘤SCID和SCID-Hu小鼠模型的样本，该模型允许可重复植入 已建立的人骨髓瘤细胞系或从MM患者新鲜分离的原代骨髓瘤细胞， 分别进行了分析。SCID-HU小鼠骨髓瘤的建立引起典型的人类多发性骨髓瘤表现 包括临床上常见的疾病异质性。动物模型核心非常适合 为孢子提供专业知识和鼠标模型，动物模型核心人员、动物 设施和组织库都位于我们机构的南校区研究大楼内 我们的实验室都集中在那里。这为核心提供了一个集成级别，可以最大限度地提高 孢子调查者对可用的动物模型和患者材料的一致性和使用。

The main goal of this Myelonna SPORE program is to develop novel targeted therapies to more effectively treat patients with multiple myeloma (MM). Clinically relevant animal models are crucial for examining the in vivo efficacy of novel agents. The dedicated personnel and facilities of the Animal Models Core (Core D) provide the program with clinically relevant animal models and expertise in animal studies essential to achieving the aims ofthe Projects. Core personnel work closely with SPORE investigators to plan animal studies and to develop optimal and clinically relevant mouse models of myeloma. During the past 5 years, the Department of Lymphoma and Myeloma and M. D. Anderson Cancer Center have provided excellent conditions in terms of access to primary myeloma samples, myeloma tissue bank, interaction between clinical and translational research programs, and animal facilities for providing unique, clinically relevant samples to establish myeloma SCID and SCID-hu mouse models, which allow reproducibly engraftment of established human myeloma cell lines or primary myeloma cells freshly isolated from patients with MM, respectively. Establishment of myeloma in SCID-hu mice induces typical human MM manifestations including disease heterogeneity commonly seen in the clinic. The Animal Models Core is well suited to provide expertise and mouse models for the SPORE given that the Animal Models Core Personnel, animal facilities, and tissue banks are all located within the South Campus Research Buildings of our institution where our laboratories are concentrated. This provides a level of integration for the Core that will maximize uniformity and use of available animal models and patients' materials by SPORE investigators.