Basic Science
Basic Science
批准号:
7930044
负责人:
Fatah Kashanchi
金额:
$15.62万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-06-01 至 2015-05-31
关键词:
AIDS/HIV problemAcquired Immunodeficiency SyndromeAnimal ModelBasic ScienceBiological AssayClinicalCollaborationsCommunicationCommunity OutreachDetectionDevelopmentDisadvantagedDiseaseFlow CytometryFosteringGene ExpressionGenomicsGoalsHIVHIV InfectionsImage AnalysisImmunologicsIndustryInstitutionInvestigationKnowledgeLaboratoriesLeadershipMentorshipMicroscopyMinorityMissionPopulationPreventionProteomicsReagentResearchResearch InfrastructureResearch PersonnelResearch SupportRuralServicesSisterTechnologyTechnology TransferTrainingTraining and EducationTranslational ResearchUnited States National Institutes of Healthdesigndrug developmentdrug discoveryinner cityinnovationprotein expressiontranslational studyviral detection
中文摘要
基础科学核心的总体目标包括:对国家CFAR任务的贡献,激励
在跨学科和转化性研究方面的科学协作,提供科学领导和
致力于艾滋病研究、促进科学交流、赞助培训的机构基础设施
和教育,促进对CFAR研究结果的了解和艾滋病研究的重要性,通过
社区外联,促进和支持国立卫生研究院艾滋病毒/艾滋病创新研究倡议,建立
CFAR之间的合作研究,并支持艾滋病毒/艾滋病研究网络,促进技术
通过促进CFAR与行业之间的科学互动进行转移和发展,以及
支持在难以接触的人群中预防和治疗艾滋病毒感染的研究,特别是在
市中心、农村贫困人口和弱势少数民族。
基础科学核心的使命是开发、完善和提供艾滋病毒/艾滋病的培训和服务
华盛顿的研究人员进行了用于评估和量化艾滋病毒复制和基因表达的分析,
使用免疫学、基因组学和蛋白质组学方法确定艾滋病毒疾病的特征,并促进药物开发
通过提供艾滋病毒疾病的小动物模型进行开发。提供的分析、试剂和培训
这一核心旨在支持预防、检测和治疗方面的基础、临床和转化性研究
艾滋病毒感染和艾滋病的治疗。
目标包括:提供技术支持和实验室服务,以促进与艾滋病毒有关的基础科学
通过获得以下服务进行研究和翻译研究,并提供指导和
为初级、少数民族和新的艾滋病毒/艾滋病调查员提供培训机会。
英文摘要
Overall goals ofthe Basic Science Core includes: contributions to the National CFAR Mission, stimulating
scientific collaboration in interdisciplinary and translational research, providing scientific leadership and
institutional infrastructure dedicated to AIDS research, fostering scientific communication, sponsoring training
and education, promoting knowledge of CFAR research findings and the importance of AIDS research through
community outreach, promoting and supporting innovative NIH HIV/AIDS research initiatives, establishing
collaborative research between CFARs, and supporting HIV/AIDS research networks, facilitating technology
transfer and development through promotion of scientific interactions between CFARs and industry, and
supporting research on prevention and treatment of HIV infection in hard-to-reach populations, especially in
inner city, rural poor, and disadvantaged minorities.
The mission ofthe Basic Science Core is to develop, refine, and provide training and services to HIV/AIDS
investigators in DC for the assays used to evaluate and quantify HIV replication and gene expression,
characterize HIV disease using immunologic, genomics and proteomics approaches, and facilitate drug
development by providing small animal models of HIV disease. The assays, reagents, and training offered by
this Core are designed to support basic, clinical, and translational research in the prevention, detection, and
treatment of HIV infection and AIDS.
The aims include: to provide technical support and laboratory services to promote HIV-related basic science
research and translational studies through access to the following services and to provide mentorship and
training opportunities for junior, minority and new HIV/AIDS investigators.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
American Society for Intercellular Communication (ASIC)
-
批准号:10753704
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2023
-
负责人:Fatah Kashanchi
-
依托单位:
Cell-derived extracellular vesicle mediated epigenetic silencing of HIV in the brain
-
批准号:10748545
-
项目类别:
-
资助金额:$63.14万
-
财政年份:2023
-
负责人:Fatah Kashanchi
-
依托单位:
American Society for Intercellular Communication (ASIC)
-
批准号:10539845
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2022
-
负责人:Fatah Kashanchi
-
依托单位:
Effect on CBD on Exosome release from CNS infected cells
-
批准号:9884894
-
项目类别:
-
资助金额:$21.1万
-
财政年份:2020
-
负责人:Fatah Kashanchi
-
依托单位:
Role of extracellular vesicles in methamphetamine and HIV induced neurotoxicity
-
批准号:9929090
-
项目类别:
-
资助金额:$0.43万
-
财政年份:2018
-
负责人:Fatah Kashanchi
-
依托单位:
A radiation-induced cellular stress activates HIV and induces killing of infected cells
-
批准号:9326140
-
项目类别:
-
资助金额:$22.8万
-
财政年份:2016
-
负责人:Fatah Kashanchi
-
依托单位:
HIV neuropathogenesis related to exosomes containing HIV non-coding RNAs
-
批准号:9136536
-
项目类别:
-
资助金额:$38.0万
-
财政年份:2016
-
负责人:Fatah Kashanchi
-
依托单位:
HIV neuropathogenesis related to exosomes containing HIV non-coding RNAs
-
批准号:9893927
-
项目类别:
-
资助金额:$37.7万
-
财政年份:2016
-
负责人:Fatah Kashanchi
-
依托单位:
A radiation-induced cellular stress activates HIV and induces killing of infected cells
-
批准号:9212863
-
项目类别:
-
资助金额:$19.0万
-
财政年份:2016
-
负责人:Fatah Kashanchi
-
依托单位:
Effect of novel cdk9 inhibitor on HIV transcription
-
批准号:8793029
-
项目类别:
-
资助金额:$20.68万
-
财政年份:2014
-
负责人:Fatah Kashanchi
-
依托单位:
Effect of novel cdk9 inhibitor on HIV transcription
-
批准号:8894397
-
项目类别:
-
资助金额:$22.09万
-
财政年份:2014
-
负责人:Fatah Kashanchi
-
依托单位:
Nanotrap particle-based assay to quantify HIV-1 in latently-infected T cells
-
批准号:8874895
-
项目类别:
-
资助金额:$22.29万
-
财政年份:2014
-
负责人:Fatah Kashanchi
-
依托单位:
Treatment of Tat neurotoxicity through the use of Gsk3-b inhibitors
-
批准号:8151114
-
项目类别:
-
资助金额:$18.26万
-
财政年份:2010
-
负责人:Fatah Kashanchi
-
依托单位:
Treatment of Tat neurotoxicity through the use of Gsk3-b inhibitors
-
批准号:8071852
-
项目类别:
-
资助金额:$22.36万
-
财政年份:2010
-
负责人:Fatah Kashanchi
-
依托单位:
Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
-
批准号:7757069
-
项目类别:
-
资助金额:$25.06万
-
财政年份:2009
-
负责人:Fatah Kashanchi
-
依托单位:
HIV-1 TAR derived miRNA: Implications for Latency and Pathogenesis
-
批准号:7685780
-
项目类别:
-
资助金额:$23.45万
-
财政年份:2009
-
负责人:Fatah Kashanchi
-
依托单位:
Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
-
批准号:8082018
-
项目类别:
-
资助金额:$18.19万
-
财政年份:2009
-
负责人:Fatah Kashanchi
-
依托单位:
HIV-1 TAR derived miRNA: Implications for Latency and Pathogenesis
-
批准号:7842609
-
项目类别:
-
资助金额:$16.6万
-
财政年份:2009
-
负责人:Fatah Kashanchi
-
依托单位:
Mechanism of activated transcription in the new HTLV-3 virus
-
批准号:7500279
-
项目类别:
-
资助金额:$19.09万
-
财政年份:2007
-
负责人:Fatah Kashanchi
-
依托单位:
Mechanism of activated transcription in the new HTLV-3 virus
-
批准号:7189157
-
项目类别:
-
资助金额:$23.26万
-
财政年份:2007
-
负责人:Fatah Kashanchi
-
依托单位:
海外基金