Measures of Dust, Endotoxin, and Exhaled Nitric Oxide among Dairy Farm Workers

呼吸道疾病在农业工人中更常见，与 其他行业的工人。然而，对工人的关注却很少。 乳制品行业。在过去的十年里，乳制品行业已经转变为依赖 更多的员工。这些工人可能会受到更大程度的接触 以及对引起肺部炎症的药物的持续时间。肺的存在 炎症也可能是哮喘、慢性支气管炎或慢性支气管炎的指标。 阻塞性肺病(COPD)。已使用呼出的NO(ENO) 广泛作为诊断哮喘和衡量其有效性的工具 哮喘治疗，然而eNO还没有被用来评估肺 大牛群奶牛场工人中的炎症。因此，这项研究将 在大型牛群奶牛场工人的样本中测量ENO。职业 还将评估这些工人暴露于粉尘和内毒素的情况。一个 将使用广义线性模型来观察杂交之间的关系 ENO的变化，以及暴露在内毒素和粉尘中。建议数 研究是创新的，因为很少有研究评估关系 肺健康与接触粉尘和内毒素等因素之间的关系 在大型牛群奶牛场工人中。这项研究的结果将有一个 对理解这两者之间的关系产生了重大影响 大型奶牛场工人的暴露与肺健康。这 研究将提供对潜在干预措施可能存在的领域的洞察 发展起来的。

Respiratory disease is more common among agricultural workers compared to workers in other industries. However, little attention has been given to workers in the dairy industry. Over the past decade, the dairy industry has changed to rely on more employees. These workers may be exposed at a greater magnitude and duration to agents which cause lung inflammation. The presence of lung inflammation may also be an indicator of asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD). Exhaled NO (eNO) has been used extensively as a tool to diagnose asthma and measure the effectiveness of asthma treatments, however eNO has not been used to evaluate lung inflammation among large herd dairy farm workers. Therefore, this study will measure eNO among a sample of large herd dairy farm workers. Occupational exposure to dust and endotoxin will also be assessed among these workers. A generalized linear model will be used to observe relationships between cross shift changes in eNO, and exposure to endotoxin and dust. The proposed research is innovative because there are few studies evaluating relationships between pulmonary health and exposure to agents such as dust and endotoxin among large herd dairy farm workers. The results of this study will have a significant impact on the understanding the relationship between these exposures and pulmonary health among large herd dairy farm workers. This study will provide insight into areas where potential interventions may be developed.