CLINICAL HEMATOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM AT WASHINGTON UNIVERSITY

描述（由申请人提供）：临床血液学研究职业发展计划在华盛顿大学准备学员（血红素学者），以解决非恶性血液疾病和输血医学的复杂问题，并缓解学术医师科学家在这些医学重要学科的短缺。学者是临床或研究员，临床或研究导师，或最近任命的助理教授。每年有一至两名学者入选该计划，为两至三年的职业发展提供支持。学者们追求的临床课程，涉及住院和门诊病人的护理与特定的非恶性血液疾病，和教学课程，教必要的独立和道德的临床研究的技能。教学课程借鉴了华盛顿大学生物统计学、流行病学、公共卫生和临床研究方面的博士后和学位授予项目的优势。每个学者参加一个密集的指导研究经验，以产生可验证的结果和初步数据，为随后的独立赠款申请。该方案侧重于三个主要领域：（1）造血干细胞和白细胞疾病，包括阵发性睡眠性血红蛋白尿症、再生障碍性贫血、先天性贫血、骨髓增生异常综合征和骨髓增生性疾病，以及使用造血干细胞的细胞疗法;（2）止血和血栓形成疾病，包括血管性血友病、血栓性微血管病和其他先天性或获得性出血或血栓形成综合征;和（3）血红蛋白病和输血医学，包括镰状细胞病和涉及输血支持或单采的临床问题。这些研究项目包括患有非恶性血液病的儿童、青少年和成人受试者。该计划旨在招募来自不同背景的优秀学者，根据他们的需求和经验个性化他们的培训，不断监测和改进课程，并跟踪学者的表现。通过这些手段，血红素学者计划预计将提高我们的国家能力，在非恶性血液学和输血医学的多学科转化和临床研究。

DESCRIPTION (provided by applicant): The Clinical Hematology Research Career Development Program at Washington University prepares trainees (Heme Scholars) to address complex problems in non-malignant blood diseases and transfusion medicine and alleviate the shortage of academic physician-scientists in these medically important disciplines. Scholars are clinical or research Fellows, clinical or research Instructors, or recently appointed Assistant Professors. One or two Scholars per year are selected for the program, which provides support for two or three years of career development. Scholars pursue a Clinical Curriculum that involves inpatient and outpatient care of patients with specific non-malignant hematologic disorders, and a Didactic Curriculum that teaches the skills necessary for independent and ethical clinical research. The Didactic Curriculum draws on the strengths of postdoctoral and degree granting programs in biostatistics, epidemiology, public health, and clinical research at Washington University. Each Scholar participates in an intensive Mentored Research Experience to generate publishable results and preliminary data for subsequent independent grant applications. The program focuses on three major areas: (1) hematopoietic stem cell and leukocyte disorders, including paroxysmal nocturnal hemoglobinuria, aplastic anemia, congenital anemias, myleodysplastic syndrome and myeloproliferative disorders, and cellular therapies using hematopoietic stem cells; (2) hemostatic and thrombotic disorders, including von Willebrand disease, thrombotic microangiopathy, and other congenital or acquired hemorrhagic or thrombotic syndromes; and (3) hemoglobinopathies and transfusion medicine, including sickle cell disease and clinical issues involving transfusion support or apheresis. These research projects encompass pediatric, adolescent and adult subjects with non-malignant hematologic disorders. The program is designed to recruit outstanding Scholars from diverse backgrounds, to individualize their training based on their needs and experience, to continuously monitor and improve the curriculum, and to track Scholar performance. By these means, the Heme Scholar program expects to increase our national capacity for multidisciplinary translational and clinical research in non-malignant hematology and transfusion medicine.