XXIII International Complement Workshop

描述（由申请人提供）：本R13资助提案要求资助研究生和博士后参加2010年8月1日至5日在纽约市举行的国际补体学会（ICS）第23届两年一次的会议。这次会议被称为国际补体研讨会（ICW），是致力于推进和传播补体系统知识的首要国际会议，补体系统是先天免疫系统的主要体液成分。预计为期5天的会议将吸引400多名与会者，其中50至60名将是研究生和博士后。此外，预计将在10次科学会议上发表300多篇摘要，涵盖补充研究的所有方面。科学主题将包括：补体结构和功能，补体激活和调节，与先天和适应性免疫的相互作用，与病原体的相互作用，补体蛋白的缺陷和多态性，炎症和自身免疫性疾病中的补体，移植中的补体。此外，将有两个主题演讲，一个临床讲座和基础科学讲座。本次会议有以下几个目标：(1)更好地了解补体系统激活和调节的分子基础；(2)更好地理解补体系统与免疫系统先天臂和适应性臂之间复杂的相互关系；(3)将来自不同学科（生物化学、生物物理学、细胞生物学、免疫学、分子生物学、结构生物学）的不同基础科学家与来自众多专业（过敏、临床免疫学、传染病、病理学、风湿病学）的临床医生聚集在一起，以更好地了解补体在免疫和传染病中的作用；(4)促进发展新的研究方法，确定疾病机制和治疗靶点，以及诊断测试和治疗；(5)教育、激励和培养互补研究领域的下一代科学家。申请的资助资金将允许许多年轻的科学家学员参加这次会议，希望ICS和学生/研究员都能从这次经历中获得长期的好处。这个R13提案是对这个拨款机制的一个非常有价值的使用。

DESCRIPTION (provided by applicant): This R13 grant proposal requests financial support for graduate students and postdoctoral fellows to attend the XXIII biennial meeting of the International Complement Society (ICS) in New York City from August 1st to 5th 2010. The meeting, known as the International Complement Workshop (ICW), is the premier international meeting dedicated to the advancement and dissemination of knowledge about the complement system, the primary humoral component of the innate immune system. It is anticipated that the 5-day meeting will attract over 400 participants, of which 50 to 60 will be graduate students and postdoctoral fellows. Moreover, it is expected that over 300 abstracts will be presented in 10 scientific sessions encompassing all aspects of complement research. Scientific topics will include: Complement Structure and Function, Complement Activation and Regulation, Interactions with Innate and Adaptive Immunity, Interactions with Pathogens, Deficiencies and Polymorphisms of Complement Proteins, Complement in Inflammatory and Autoimmune Diseases, Complement in Transplantation. In addition, there will be two keynote presentations, one clinical lecture and basic science talk. There are several objectives for this meeting which are as follows: (1) to provide a better understanding of the molecular basis for the activation and regulation of the complement system; (2) to better comprehend the complex interrelationships between complement system and the innate and adaptive arms of the immune system; (3) to bring together a diverse group of basic scientists from several disciplines (biochemistry, biophysics, cell biology, immunology, molecular biology, structural biology) together with clinicians from numerous specialties (allergy, clinical immunology, infectious diseases, pathology, rheumatology) to better understand the role complement plays in immune and infectious diseases; (4) to promote the development of new research approaches, identification of disease mechanisms and targets for therapeutics, and diagnostic tests and treatments; and (5) to educate, motivate and foster the next generation of scientists in the field of complement research. The requested grant funds will permit many young scientist trainees to participate in this meeting, and hopefully, both the ICS and the students/fellows will reap long-term benefits from this experience. This R13 proposal is a very worthwhile use of this grant mechanism.