SAFETY OF MESENCHYMAL STEM CELL ADMINISTRATION TO THE CNS OF RHESUS MACAQUES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 该项目的总体目标是在非人灵长类动物中评估骨髓间充质干细胞（MSC）作为治疗神经系统疾病的细胞载体的安全性和潜在疗效。 具体而言，将MSC直接移植到CNS中，并评估其在脑中的总体植入和解剖分布。 在MSC施用之前和之后，使动物经受一系列行为和运动性能测试。 将MSC植入与对行为和运动表现的影响相关联提供了一种评估MSC治疗神经系统疾病的安全性和总体效用的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to evaluate in non-human primates the safety and potential efficacy of bone marrow-derived mesenchymal stem cells (MSCs) as cellular vectors for treating neurologic diseases. Specifically, MSCs are transplanted directly into the CNS and their overall engraftment and anatomic distribution in brain is evaluated. Prior to and after MSC administration animals are subjected to a battery of behavioral and motor performance tests. Correlating MSC engraftment with affects on behavior and motor performance provides a means to evaluate the safety and overall utility of MSCs for treating neurologic diseases.