Molecular Regulation of Tissue-Resident Memory T cell Differentiation

最近发现的位于病原体入口点的T细胞亚群对对抗病毒感染至关重要。然而，人们对这些T细胞群是如何形成的知之甚少。这个项目将描述产生这些细胞所需的途径，并将确定调节它们发育的新因素。更深入地了解这些T细胞是如何产生的，将为在新的疫苗策略中利用这些细胞开辟道路。

A recently identified subset of T cells that reside at points of pathogen entry are critical to combat viral infection. However, little is known about how these T cell populations are formed. This project will characterise the pathways required to generate these cells and will identify novel factors that regulate their development. A greater understanding of how these T cells can be generated will open the way to utilise these cells in new vaccine strategies.