ATSDR/MESL Exposure-Dose Reconstruction Program

描述(由申请人提供) 建议进行一项全面的研究，以帮助了解影响污染物在环境中迁移的命运和迁移过程。另一个目标是开发创新的基于风险的方法和计算工具，可用于模拟污染物在环境中的迁移模式。为此，我们建议开发模块化计算工具，其中将包括地表水、地下水、空气和其他工程管道路径的机械模型。拟议的模块模型将使用概率和可能性理论与基于风险的风险敞口分析模型相联系。机械模拟将被用来理解和联系环境因素对污染物在环境中的空间和时间扩散的影响。基于风险的暴露分析将用于通过标准暴露途径量化健康风险，并将基于输入参数的可变性和不确定性以及开发的概念模型的不确定性。其目标是为管理人员和健康科学家提供基于风险的模块化模拟工具，以在人类接触水平上评估环境中的污染物浓度水平，以便预防措施和决策可以与透明和可重复的数据联系在一起。

Description (Provided by Applicant) A comprehensive study is proposed to aid in understanding the fate and transport processes that affect the migration of contaminants in the environment. The other goal is the development of innovative risk-based methodologies and computational tools, which can be used to simulate the migration patterns of contaminants in the environment. For this purpose, we propose the development of modular computational tools, which will include mechanistic models for surface water, groundwater, air and other engineered conduit pathways. The proposed modular models will be linked to risk-based exposure analysis models using probability and possibility theory. The mechanistic modeling will be used to understand and link the effect of environmental factors on spatial and temporal spread of contaminants in the environment. The risk-based exposure analysis will be used to quantify the health risk through standard exposure pathways, and will be based on variability and uncertainty in input parameters as well as uncertainty in conceptual models developed. The goal is to provide managers and health scientists, risk-based modular simulation tools to evaluate contaminant concentration levels in the environment at the human contact level so that preventative measures and decisions can be tied to transparent and reproducible data.