Virology

病毒学 病毒学计划的目标是继续确定人类肿瘤病毒诱发癌症的机制，并利用这些发现开发针对这些过程的翻译研究。 主要的计划领域是免疫、发病机制、VIMS：细胞相互作用和艾滋病相关癌症：A。)免疫小组一直专注于开发有效的病毒感染和癌症新疫苗，基因传递的病毒载体，以及识别病毒感染对先天免疫和炎症的影响。甲型流感和冠状病毒对先天免疫有很强的影响，它们损害这种反应的机制正在研究中。此外，EBV和 KSHV对干扰素调节因子和Toll样受体的影响正在研究中。B.)病理学组分析了人类肿瘤标本，以确定病毒对细胞生长和表达的影响，并开发了转基因小鼠来模拟与这些病毒相关的恶性肿瘤。(C)VimsiCell Interaction的研究揭示了EBV和KSHV对泛素途径的影响，包括鉴定病毒编码的脱泛素酶，并分析了PI3K/Akt/pcatenin和NFKB途径的病毒激活。D.)对艾滋病病毒引起的癌症的研究正在扩大，NCI最近为艾滋病相关癌症的研究提供了三项补充赠款。 已经开始了实验性的翻译研究，以治疗艾滋病相关的淋巴瘤并确定口腔HPV感染的特征。研究人类疱疹病毒的三名研究人员是通过病毒学项目赠款资助的，这些项目基于新开发的技术，这些技术可通过Lineberger癌症中心共享资源，包括蛋白质组学核心和Next 世代排序。该计划的新成员研究人源化小鼠模型、丙型肝炎病毒和人乳头瘤病毒(HPV)中的病毒感染。通过临床标本、体外转化系统和动物模型的研究，将进一步分析人类肿瘤病毒EBV、KSH‘V、丙型肝炎病毒和人乳头瘤病毒的病原学贡献。该计划的未来计划包括招聘更多的 病毒相关性癌症的研究人员以及针对这些癌症的特定抗病毒和免疫疗法的扩展，特别侧重于艾滋病恶性肿瘤的实验疗法。

Virology The goals of the Virology Program are to continue to identify the mechanisms through which human tumor viruses induce cancer and to use these findings to develop translational studies that target these processes. The major programmatic areas are Immunity, Pathogenesis, Vims:Cell Interactions, and AIDS-associated Cancers: A.) The Immunity group has focused on the development of effective new vaccines for viral infection and cancer, viral vectors for gene delivery, and the identification of the effects of viral infection on innate immunity and inflammation. Alphavimses and corona viruses have powerful effects on innate immunity and their mechanisms to impair this response are under study. Additionally, the effects of EBV and KSHV on interferon regulatory factors and toll-like receptors are under study. B.) The Pathogenesis group analyzes human tumor specimens to identify the viral effects on cell growth and expression and have developed transgenic mice to model the malignancies associated with these viruses. C.) The VimsiCell Interaction's studies have revealed effects of EBV and KSHV on the ubiquitin pathway including the identification of virally encoded deubiquitinases, and have analyzed viral activation of the PI3kinase/Akt/pcatenin and NFKB pathways. D.) The study of AIDS-associated virally induced cancers is expanding and three NCI supplemental grants for the study of AIDS-associated cancers have been recently funded. Experimental translational studies have been initiated to treat AIDS-associated lymphomas and characterize oral HPV infection. Three of the investigators that study human herpesvimses are funded through a Virology Program Project grant with projects that are based on newly developed technologies that are available through the Lineberger Cancer Center shared resources, including the Proteomics Core and Next Generation Sequencing. New members of the Program study viral infections in humanized mouse models, HCV, and human papilloma virus (HPV). The etiologic contributions of the human tumor viruses, EBV, KSH'V, HCV, and HPV will be further analyzed through the study of clinical samples, in vitro transformation systems, and animal models. The future plans for the Program include recruitment of additional investigators in virally-associated cancers and the expansion of specific anti-viral and immuno-therapies for these cancers with specific focus on experimental therapeutics for AIDS malignancies.