IBD and Mucosal Inflammation, Immunology, and Microbiology of the GI Tract

本申请是为了竞争性更新芝加哥大学消化系统疾病研究核心中心（DDRCC），该中心自1990年以来一直存在。该DDRCC的首要主题是炎症性肠病（IBD）和IBD相关领域的研究，包括GI炎症性疾病的免疫学，微生物学和遗传学。在上一个供资周期，复员方案协调中心的领导、行政结构和研究基础保持了稳定性，有利于在复员方案协调中心成员之间建立强有力的互动网络。该研究基地是高度多学科的，目前每年的直接费用总额为1160万美元，其中40%或465万美元由NIDDK支持。这一数额略高于上次竞争性续约报告的数额。学术水平仍然很高，由此产生的出版物中有40%以上涉及DDRCC成员之间的共同作者。试点和可行性计划成功地促进了新研究者的发展，并吸引了来自其他领域的知名科学家参与IBD的研究。他们的项目的新奇和优点导致了获得后续校外资助的成功率非常高。充实方案为解除武装、复员和重返社会协调中心成员提供了继续教育和培训，并通过其互动方案，提出了若干新的方案倡议。随着该领域的迅速发展和新技术的出现，复员方案协调中心成功地预见到了复员方案协调中心调查员的需求和活动。综合转化核心（取代临床部分）已成为DDRCC的主要基础，将临床和基础研究联系起来，为合作转化研究创造了前所未有的机会。宿主-微生物核心（以前的细胞生物学核心）提供了广泛的实验系统来了解宿主-微生物相互作用，包括gnotobiotic小鼠技术和研究肠道微生物组的新一代分子方法。基因组学和分子工程以及组织和细胞分析核心也不断发展，以提供适用于人类和实验研究的尖端技术。总之，复员方案协调委员会积极促进其成员之间的互动与协作。通过其具有成本效益的技术和服务，DDRCC一直是芝加哥大学IBD和消化系统疾病学术和发现进步的主要因素。

This application is for the competitive renewal of the Digestive Diseases Research Core Center (DDRCC) at the University of Chicago which has been in existence since 1990. The overarching theme of this DDRCC is the study of inflammatory bowel diseases (IBD) and IBD-related areas, including the immunology, microbiology, and genetics of Gl inflammatory disorders. Over the past funding cycle, the leadership, administrative structure, and research base of the DDRCC have provided a constancy that has been conducive to the development of robust and interactive networks among DDRCC members. The research base is highly multidisciplinary and currently has an annual total direct cost of $11.6 million, of which 40% or $4.65 million is supported by NIDDK. This amount is slightly greater than that reported for the last competitive renewal. The level of scholarship continues to be outstanding where over 40% of the resulting publications involve shared authorships among DDRCC members. The Pilot and Feasibility program has successfully promoted the development of new investigators and attracted established scientists from other fields to the study of IBD. The novelty and merits of their projects have led to a very high success rate in obtaining subsequent extramural funding. The enrichment program has provided continuing education and training for DDRCC members and, through its interactive programs, several new programmatic initiatives have emerged. With the rapid advances in the field and the emergence of new technologies, the DDRCC has successfully anticipated the needs and activities of DDRCC investigators. The Integrated Translational core (replacing the clinical component) has become a major underpinning of the DDRCC, linking clinical and basic research and creating unprecedented opportunities for collaborative translational research. The Host-Microbe core (formerly the Cell Biology core) provides a wide range of experimental systems to understand host-microbe interactions, including gnotobiotic mouse technology and new generation molecular approaches for studying the enteric microbiome. The Genomics and Molecular Engineering and Tissue and Cell Analysis Cores have also evolved to provide cutting edge technologies applicable to human-based and experimental research. In summary, the DDRCC has proactively promoted interaction and collaboration among its members. Through its cost-effective, enabling technologies and services, the DDRCC has been a major factor in the advancement of scholarship and discovery in IBD and digestive diseases at the University of Chicago.