International Core (Page 577)

HNRC已经扩大了其国际重点，以认识到增加知识的机会 艾滋病毒的神经病理学，可以解决唯一的资源有限的设置（RLS）。的 相关的科学主题包括病毒和宿主遗传和线粒体因素的影响;可用性， 抗病毒治疗的效力和时机;区域特异性辅因子（例如，共感染暴露 病原体、特定的滥用药物、创伤）;以及社会文化和环境差异如何影响 流行病学，现象学，发病机制和治疗神经艾滋病的有效性。 方法学问题包括发展有效的神经认知和日常功能评估， 在不同的语言和文化环境中以及在文盲或半文盲中使用， 神经医学确定方法在RLS中成功部署。国际核心建议， 确定国际研究的机会，并促进HNRC调查人员之间的伙伴关系， RLS的科学家-临床医生，以建立进行符合 HNRC的科学主题，这是响应这些设置的需要和情况。核心 协调科学咨询、指导、培训和技术援助， 合作，赞助商发起的，可资助的神经艾滋病国际研究计划。我们有 为3次国际神经艾滋病培训会议获得了NIH U-13赠款，并创建了国际 神经艾滋病科学家联盟在会议期间保持研究人员之间的联系。期间 在上一个供资期，国际核心支助了（1）对一项R- 中国两个高危人群HIV神经认知并发症的研究（2）围产期HIV神经认知并发症的R-21研究 感染的罗马尼亚青少年，（3）巴西神经艾滋病的R21研究，（4）神经认知的R 01研究 在印度浦那开始抗病毒治疗后的损伤，和（5）一项R 01研究病毒分支对 在上述四个地点和美国的神经艾滋病，以及一些较小的发展项目。 国际核心网站整合了信息，并为获取资源提供便利。我们的计划 为国际同事提供现场培训和发展赠款（与发展部协调） 核心）促进了多项发展研究，我们的通信和数据管理 能力方案协助了几个国际合作地点的调查人员。

The HNRC has expanded its international focus in recognition of opportunities for incremental knowldge of the neuropathology of HIV that can be addressed uniquely in resource-limited settings (RLS). The pertinent scientific topics include effects of viral and host genetic and mitochondrial factors; availability, efficacy, and timing of antiviral treatments; region-specific cofactors (e.g., exposure to co-infecting pathogens, specific drugs of abuse, trauma); and how sociocultural and environment differences affect the epidemiology, phenomenology, pathogenesis, and effectiveness of treatment for of neuroAIDS. Methodological issues include development of valid assessments of neurocognitive and daily functioning for use in diverse linguistic and cultural settings and in illiterate or semiliterate persons, as well as adaptation of neuromedical ascertainment methods for successful deployment in RLS. The International Core proposes to identify opportunities for international research and to facilitate partnering between HNRC investigators and scientist-clinicians in RLS in order to build capacity to undertake neuroAIDS research that is in line with HNRC scientific themes, and that is responsive to the needs and circumstances of those settings. The Core has coordinated scientific consultation, mentoring, training, and technical assistance designed to develop collaborative, investigator-initiated, fundable international research programs on NeuroAIDS. We have secured an NIH U-13 grant for 3 international NeuroAIDs training meetings and created the International Consortium of NeuroAIDS Scientists to maintain contact among investigators between meetings. During the last funding period, the International Core supported (1) baseline and multiple follow-up evaluations for an R- 01 study of HIV neurocognitive complications in two risk groups in China, (2) an R-21 study of perinatally infected Romanian adolescents, (3) an R21 study of NeuroAIDS in Brazil, (4) an R01 study of neurocognitive impairment after antiviral treatment initiation in Pune, India, and (5) an R01 study of effects of viral clade on neuroAIDS in four of the above sites and the US, as well as a number of smaller developmental projects. The International Core website consolidates information and facilitates access to resources. Our programs of on-site training and developmental grants for international colleagues (in coordination with Developmental Core) have promoted multiple developmental studies, and our communications and data management capacity has assisted investigators at several collaborating international sites.