Alphaherpesvirus vaccination, recombination and latency; a study in the natural host

甲型疱疹病毒减毒疫苗被广泛用于生产和同伴动物，以帮助控制疾病。这些疫苗有助于防止在受到强毒病毒攻击后出现疾病的临床症状。还有可能使用这些疫苗来帮助预防潜伏的疱疹病毒感染，并限制疱疹病毒重组发生的机会。这将提高控制动物种群疾病的能力。该项目旨在通过研究自然宿主中的禽传染性喉气管炎病毒，系统地研究如何使用疫苗来限制潜伏期和重组事件，从而对如何更有效地使用疫苗提供新的见解。

Attenuated alphaherpesvirus vaccines are used widely in production and companion animals to help control disease. These vaccines help to prevent clinical signs of disease following challenge with virulent viruses. There is also the potential to use these vaccines to help prevent latent herpesvirus infections, and to limit the opportunities for herpesvirus recombination to occur. This would enhance the ability to control disease in animal populations. This project aims to systematically study how vaccines may be used to limit latency and recombination events by studying avian infectious laryngotracheitis virus in the natural host leading to new insights into how vaccines may be used more efficaciously.