Training Core

机动性对人类健康至关重要。规律的体育锻炼有助于预防心脏病和中风， 缓解抑郁症状，促进减肥。不幸的是，许多条件，例如 脑性瘫痪、骨关节炎和肥胖限制了行动能力，给个人和社会带来了巨大的代价。而当 从数百个研究实验室和数百万部智能手机中可以获得海量数据， 缺乏分析这种海量、不同种类的数据集的方法。 我们建议建立全国移动数据集成到洞察中心(The Mobiled Center) 为了克服移动大数据和生物医学大数据普遍面临的数据科学挑战。我们的 初步工作确定了数据科学中的四个瓶颈，这些瓶颈驱动了四个数据科学研究核心。 核心包括生物力学建模、统计学习、行为和社会建模，以及 综合建模和预测。我们的核心将产生新的方法来集成不同的建模 并从嘈杂、稀疏、异类和时变的大数据中获得洞察力。我们的数据共享联盟与临床、研究和行业合作伙伴将为1000多万人提供移动性数据。 三个推动生物医学的问题将集中并验证我们的数据科学研究。 移动中心将把我们的新型数据科学工具传播给成千上万的研究人员和 创建一个可持续的数据共享联盟。我们将通过我们的面对面和在线教育项目，培训数万名科学家在生物医学中使用数据科学方法。我们将通过经验丰富的执行团队的领导，建立一个有凝聚力、充满活力和可持续发展的国家中心，并将通过我们的生物医学计算评论出版物和Simtk.org资源门户网站帮助统一BD2K财团。动员中心将为下一代数据科学系统奠定基础，并为数百万受行动不便影响的人的诊断和治疗带来革命性变化。

Mobility is essential for human health. Regular physical activity helps prevent heart disease and stroke, relieves symptoms of depression, and promotes weight loss. Unfortunately, many conditions, such as cerebral palsy, osteoarthritis, and obesity, limit mobility at an enormous personal and societal cost. While vast amounts of data are available from hundreds of research labs and millions of smartphones, there is a dearth of methods for analyzing this massive, heterogeneous dataset. We propose to establish the National Center for Mobility Data Integration to Insight (the Mobilize Center) to overcome the data science challenges facing mobility big data and biomedical big data in general. Our preliminary work identified four bottlenecks in data science, which drive four Data Science Research Cores. The Cores include Biomechanical Modeling, Statistical Learning, Behavioral and Social Modeling, and Integrative Modeling and Prediction. Our Cores will produce novel methods to integrate diverse modeling modalities and gain insight from noisy, sparse, heterogeneous, and time-varying big data. Our data-sharing consortia, with clinical, research, and industry partners, will provide mobility data for over ten million people. Three Driving Biomedical Problems will focus and validate our data science research. The Mobilize Center will disseminate our novel data science tools to thousands of researchers and create a sustainable data-sharing consortia. We will train tens of thousands of scientists to use data science methods in biomedicine through our in-person and online educational programs. We will establish a cohesive, vibrant, and sustainable National Center through the leadership of an experienced executive team and will help unify the BD2K consortia through our Biomedical Computation Review publication and the Simtk.org resource portal. The Mobilize Center will lay the groundwork for the next generation of data science systems and revolutionize diagnosis and treatment for millions of people affected by limited mobility.