Office of Intramural Research Scientific Computing Facility

校内研究办公室(OIR)科学计算设施(SCF)与OIR工作人员和他们的NIH调查人员合作，建立一个多样化和强大的科学计算系统。该系统提供合作所需的基础设施，同时遵守所有安全、保密和完整性要求，特别是与存储PII和其他敏感数据有关的要求。云函数管理硬件更新和软件升级，让协作者可以不间断地工作。专家工作人员能够提供集中的支持和建议，以便能够最佳地利用资源来支持OIR的研究计划。 作为计算科学研究和开发组织的核心部分，SCF充当了OIR的计算实验室，为OIR的许多合作努力做出了贡献，并为许多NIH研究人员和领导者提供了关键资源。SCF支持约100个系统的约80名OIR工作人员和协作者，运行各种网络服务、数据库、文件存储、计算集群和大核数量的单映像计算机。SCF有单独的机架，用于存储和处理敏感信息，如个人健康信息和赠款信息，并有适当的额外保护层。 一个跨所有计算系统的通用联合环境，使OIR工作人员能够快速构建他们在整个协作生命周期中所需的数据分析工具。通用文件系统、统一身份验证、系统管理和其他系统协调功能完全集成到包含所需各种支持软件的基础架构中。商品硬件、自由软件和商业软件被整合为高效和可持续的解决方案。 SCF员工代表OIR执行科学计算系统日常运行所需的许多常见安全、维护、备份和报告任务。特别是，在OIR的计算设施上管理联邦授权的认证和认可流程，否则将给OIR的开发人员和调查人员及其合作者带来沉重的负担。当协作项目结束时，SCF在将系统重新部署到IC或CIT数据中心内的空间方面发挥着核心作用。 在与NHLBI的合作中，SCF向NIH更广泛的Linux社区提供战略拓展，与CIT合作提供基础设施支持。在过去5年中，我们开发了AD集成配置、独立服务器配置、双因素身份验证解决方案、NFS/Krb5集成，以及对NHLBI内部研究部的一般Linux支持。 2016年，支持的协作包括： 。人类唾液蛋白质目录，与NIDCR，支持唾液蛋白质组社区。 。分子结构测定(NIDDK、NIDCR、NCI、NHLBI)。 。分子建模中心的MMIGNET计划作为一个整体支持NIH。 。具有NCI和NIAID的微阵列数据库系统(MAdb)。 。投资组合分析和投资组合可视化资源，支持整个NIH的许多小组，包括OD、CSR和NIGMS。 。与NHLBI合作设计和执行一个程序，该程序计算数十亿个SNP-基因表达关联测试，以努力发现表达-单核苷酸多态，eSNPs。到目前为止的努力正在产生比之前的努力快20倍的速度。 。与NCI和NCI资助的一个财团的联合项目，实施分析管道，并提供必要的生物信息学工具，用于转录组分析和对来自下一代测序的RNA-seq/exon捕获数据进行生物学解释。 。与NHLBI和其他IC的联合项目，提供计算系统管理支持，并为NIH制定政策和标准。

The Office of Intramural Research (OIR) Scientific Computing Facility (SCF) collaborates with OIR staff and their NIH investigators to build a diverse and robust scientific computing system. This system provides the infrastructure needed by the collaborations at the same time as complying with all security, confidentiality and integrity requirements, especially those concerned with storing PII and other sensitive data. The SCF manages hardware refreshes and software upgrades allowing collaborators to work uninterrupted. Expert staff are able to provide centralised support and advice to enable the best use of resources in support of OIR's research program. As a central part of a computational science research and development organization, the SCF acts as OIR's computational laboratory, contributing on many of OIR's collaborative efforts and providing many NIH investigators and leaders with a key resource. The SCF supports some 80 OIR staff and collaborators across approximately 100 systems, running a variety of web services, databases, file storage, computational clusters and large core count single image machines. The SCF has separate racks for machines used for storing and processing sensitive information, such as personal health information and grant information, with appropriate extra layers of protection. A common and federated environment across all computational systems, enables OIR staff to quickly build the data analysis tools they need throughout the lifetime of a collaboration. Common file systems, unified authentication, system management, and other system coordinating features are fully integrated into an infrastructure containing the required variety of supporting software. Commodity hardware, free software and commercial software are integrated into efficient and sustainable solutions. SCF Staff perform the many common security, maintenance, backup and reporting tasks that are required for the day to day operation of scientific computational systems on behalf of OIR. In particular, managing the Federally mandated Certification and Accreditation process on OIR's Computational Facility that would otherwise be a significant burden to OIR developers and investigators as well as their collaborators. When an collaborative project is concluded, the SCF is central in relocating systems to space within the ICs or the CIT Data Center as appropriate. In collaboration with NHLBI, the SCF provides strategic outreach to the wider Linux community at NIH, working with CIT to provide infrastructure support. Over the last 5 years we have developed AD integration configurations, stand-alone server configurations, two-factor authentication solutions, NFS/Krb5 integrations, as well as general Linux support for the NHLBI Division of Intramural Research. In 2016, supported collaborations include: . The Human Salivary Protein Catalog, with NIDCR, supporting the Salivary Proteome community. . Molecular Structure Determination (NIDDK, NIDCR, NCI, NHLBI). . The Center for Molecular Modeling's MMIGNET programme supporting NIH as a whole. . Microarray Database System (mAdb) with NCI and NIAID. . Portfolio analysis and portfolio visualization resources supporting many groups throughout NIH, including OD, CSR and NIGMS. . A collaborative effort with NHLBI to design and execute a program which computes billions of SNP-gene expression association tests, in an effort to find expression - single nucleotide polymorphisms, eSNPs. Efforts so far are producing a 20-fold speed up over previous efforts. . A joint project, with NCI and a NCI-funded consortium, implementing an analysis pipeline and providing the necessary bioinformatics tools for transcriptome analysis and biological interpretation of RNA-seq/Exon capture data from next generation sequencing. . A joint project with NHLBI and other ICs to provide a nexus of computational system administration support and set policies and standards for NIH.