Immunobiology of Myeloid and Lymphoid Cells

摘要 我们建议提高盖泽尔医学院免疫学培训计划的质量 在由NIH T32拨款支持的达特茅斯(GSOM)，“髓系免疫生物学和 “淋巴样细胞”，在过去的25年里。该应用程序的总体目标是培养最好的毕业生 学生和博士后研究人员成为有道德、有生产力和消息灵通的独立 调查人员。这项培训拨款的科学重点是发现和理解免疫系统是如何 系统和免疫细胞在健康和疾病中发挥作用。拟议的培训是多方面的，包括 实验室研究的设计、战略和解释，研究的伦理和可重复的行为， 指导职业生涯规划，增强写作和演示技巧。科学训练发生在 无论是动物系统还是人类系统。该计划的教职员工的研究兴趣涉及免疫学的广泛领域 允许学员有相当广泛的概念和实验选择的领域 研究课题。研究课题包括但不限于抗原递呈和诱导 免疫，抗病毒免疫，肿瘤免疫和免疫治疗，炎症，疫苗，粘膜 豁免权、免疫力调节和自身免疫力。该提案的一个关键优势是高质量的 来自GSOM和塞耶学院的16名教员培训人员的研究计划 工程学。GSOM拥有卓越的研究设施，特别是在威廉姆斯的加入下 翻译研究大楼于2015年建成。这些实验室装备齐全，可以支持各种状态的 在免疫学、生物化学和分子生物学技术方面的最新研究。达特茅斯有AAALAC 经批准的动物设施。达特茅斯建立了一所新的研究生和高级研究学院， 专门为培养研究生和博士后的专业发展和成功而设计的。 免疫学培训跨越几个研究生项目：分子和细胞生物学，该项目在 实验和分子医学，以及定量生物医学科学计划。与一致 为了满足未来科学家的需求，达特茅斯的免疫学培训涉及到多学科/跨学科的方法 受到高度互动的环境的熏陶。学生和博士后研究员受益于充满活力的教职员工 达特茅斯亲密师生传统的参与和科学交流 互动。除了经典的科学培训，我们还提供专业发展课程和 帮助学生、博士后研究员和教师在职业生涯中取得成功的研讨会。免疫学 计划有出色的成功记录，我们建议在此成功的基础上教育和 促进下一代免疫学研究科学家的培养。

Abstract We propose to improve the quality of the Immunology Training Program at the Geisel School of Medicine at Dartmouth (GSOM) that has been supported by the NIH T32 grant, “Immunobiology of myeloid and lymphoid cells”, for the past twenty-five years. The overall goal of this application is to train the best graduate students and postdoctoral researchers to become ethical, productive, and well-informed independent investigators. The scientific focus of this training grant is the discovery and understanding of how the immune system and immune cells function in health and disease. The training proposed is multi-faceted, and includes design, strategy and interpretation of laboratory research, ethical and reproducible conduct of research, mentorship with career planning, and enhanced writing and presentation skills. Scientific training occurs in both animal and human systems. The program faculty's research interests span a wide range of immunologic areas that allows entering trainees a considerable breadth of conceptual and experimental choices of research topics. Research topics include, but are not limited to, antigen presentation and induction of immunity, immunity against viruses, tumor immunity and immunotherapy, inflammation, vaccines, mucosal immunity, regulation of immunity, and autoimmunity. A critical strength of the proposal is the high quality of the research programs of the sixteen faculty trainers, drawn from GSOM and the Thayer School of Engineering. GSOM has outstanding research facilities, especially with the addition of the Williams translational research building in 2015. The laboratories are fully equipped to support a full-range of state-of- the-art research in immunology, biochemistry, and molecular biology techniques. Dartmouth has AAALAC approved animal facilities. Dartmouth has founded a new School in Graduate and Advanced Studies that is designed specifically to foster the professional development and success of graduate students and postdocs. Training in immunology spans several graduate programs: Molecular and Cell Biology, the Program in Experimental and Molecular Medicine, and the Program in Quantitative Biomedical Sciences. Consistent with the needs of future scientists, Immunology training at Dartmouth involves a multi/interdisciplinary approach nurtured by a highly interactive environment. Students and postdoctoral fellows benefit from a vigorous faculty involvement and scientific exchanges characteristic of the Dartmouth tradition of close student-faculty interactions. In addition to classic scientific training, we offer professional development courses and workshops to help students, postdoctoral fellows, and faculty succeed in their careers. The Immunology Program has an outstanding track record of success, and we propose to build on this success to educate and promote the next generation of research scientists in immunology.