Core B - Clinical Core

临床核心项目摘要/摘要 临床核心的使命与整个MADRC的使命相似：支持对病因的研究， 阿尔茨海默病和相关痴呆的机制和治疗，最终目标是治愈甚至预防 这些障碍。当1984年首次成立时，我们的大部分工作都集中在AD方面，从AD痴呆症开始 和扩展到轻度认知障碍(MCI)。在过去的5年里，随着调查人员的增加，调查的重点扩大了 在核心制定了具体的研究项目，研究血管认知障碍，帕金森病 痴呆/路易体痴呆和额颞叶痴呆。我们现在将我们的核心进一步扩展到 强调有痴呆风险的正常老年人和主观者的行为和生物学特征 认知方面的问题。为了促进这些领域的临床研究，我们已经建立并维持了一个 来自不同种族和种族背景的男性和女性的纵向队列(LC)横跨整个范围 认知功能从正常到主诉到MCI再到痴呆症。全面系统 对这一队列的检查是临床核心任务的核心。从这个刻画得很好的纵向 跟随队列，我们提供及时准确的数据提交给NACC；国家多中心课题 研究如ADNI、DIAN和ADCS试验；以及用于遗传和生物标记物研究的生物样本。这个 LC也为我们中心的本地研究提供支持：我们将继续支持40多项依赖于 关于我们的评估和我们的受试者，他们的数据和/或他们的生物液是否成功，包括项目1和2 在这份续签申请中。我们核心的一个特别强调，与我们中心的理解和 识别疾病的最早阶段，是开发新的评估工具，可以用于我们的 以及其他人在这一领域的研究。我们还将把受试者推荐到新的神经成像核心，在 支持外联核心的新征聘登记处，并与神经病理学协调 核心，以促进顺利的尸检协议。核心将与外联核心一起提高认识 关于阿尔茨海默病和痴呆症，并协助增加少数族裔受试者获得LC和 研究项目。核心的最终目标是帮助培训下一代调查人员，我们将继续 吸引有前途的临床科学家，为他们的职业发展提供一个激励的环境。

CLINICAL CORE PROJECT SUMMARY/ABSTRACT The mission of the Clinical Core parallels that of the MADRC as a whole: To support research into the causes, mechanisms and treatment of AD and related dementias, with the eventual goal of curing and even preventing these disorders. When first established in 1984, much of our work centered on AD, beginning with AD dementia and expanding to Mild Cognitive Impairment (MCI). The focus broadened over the past 5 years as investigators in the Core developed specific research programs in vascular cognitive impairment, Parkinson disease dementia/dementia with Lewy bodies, and frontotemporal dementia. We now expand our Core's focus further to emphasize the behavioral and biological features of normal elders at risk for dementia and those with subjective cognitive concerns. In order to facilitate clinical research in these areas, we have established and maintain a Longitudinal Cohort (LC) of men and women from diverse ethnic and racial backgrounds spanning a full range of cognitive function from normal to subjective complaints to MCI to dementia. Comprehensive and systematic examination of this cohort is central to the Clinical Core mission. From this well-characterized and longitudinally followed cohort, we provide timely and accurate data submission to NACC; subjects for national multi-center studies such as ADNI, DIAN and ADCS trials; and biological samples for genetic and biomarker research. The LC also fuels our Center's local research studies: we will continue to support the more than 40 studies that rely on our evaluations and our subjects, their data and/or their biologic fluids for success, including Projects 1 and 2 in this renewal application. A special emphasis of our Core, in line with our Center's theme of understanding and recognizing the earliest phase of disease, is the development of novel assessment tools that can be used in our and others' studies in this area. We will also work on referring subjects to the new Neuroimaging Core, on supporting the new Recruitment Registry in the Outreach Core, and on coordinating with the Neuropathology Core to facilitate smooth autopsy protocols. The Core will join with the Outreach Core in raising awareness about AD and dementias, and assist in increasing the number of minority subjects who have access to LC and research projects. A final goal of the Core is help train the next generation of investigators, and we will continue to attract promising clinician-scientists and provide a stimulating environment for their career development.