Physical Activity, Weight Gain, and Risk for Knee Osteoarthritis after Traumatic Knee Injury

项目摘要 青少年和成年早期的创伤性膝关节损伤导致体育活动突然停止。的 回归运动的后续轨迹及其对长期身体活动行为、体重 增益，并最终膝关节骨关节炎（OA）是未知的。一个可能的后果是体重增加。肥胖症 除膝关节损伤外，是膝关节OA发生和进展的已知风险因素。因此，重量 受伤后的收益可能会加速OA的发展并增加早期关节置换的风险 功能衰退。这项奖学金申请的长期目标是准备申请人成为一个 一位成功的独立科学家专注于成年早期受伤的后果， 预防/延缓慢性疾病的发展，优化长期生活质量。作为实现这一目标的一步 目标，本提案的目标是评估体育活动，身体活动，体重增加，以及 膝关节损伤后膝关节OA的发展。中心假设是膝关节置换术后运动活动的减少 受伤导致体重增加，随后增加了不活动和膝关节OA事件的风险。 长期的该提案利用了一项正在进行的临床和功能结局的纵向研究， 膝关节损伤后，特别是前交叉韧带损伤和重建（n=150）。结局数据 在基线（受伤后不久）和6个月，1年，2年，5年随访时收集。10年 后续数据收集工作正在进行。目标1将确定1至5年的体育活动轨迹 以及这些轨迹与10年时身体活动的关联。目标2将 立即（基线至6个月）和短期（1至5年）研究体重变化 膝盖受伤后，以及体重变化与体育活动的关系。目标3将评估体育协会 活动和体重状况与膝关节损伤后发生膝关节OA的关系。该提案的结果将提供一个 批判性地理解与受伤后不活动相关的潜在健康后果，并推动 制定长期策略，通过体育活动和健康体重在受伤后保持膝盖健康， 这不是当前损伤后干预的焦点。通过在指导下完成这项研究， 在强大的环境中经验丰富的导师，申请人将准备开始职业生涯， 研究肌肉骨骼损伤后果的独立科学家。

PROJECT SUMMARY A traumatic knee injury in adolescence and early adulthood results in an abrupt halt to sports activity. The subsequent trajectories of a return to sports and their effects on long-term physical activity behavior, weight gain, and ultimately knee osteoarthritis (OA) are not known. One likely consequence is weight gain. Obesity, in addition to knee injury, is a known risk factor for the development and progression of knee OA. Thus, weight gain following injury may accelerate the development of OA and increase the risk for early joint replacement and functional decline. The long-term objective of this fellowship application is to prepare the applicant to be a successful independent scientist focused on the consequences of injury in early adulthood in order to prevent/delay the development of chronic disease and optimize long-term quality of life. As a step towards this goal, the objective of this proposal is to evaluate sports activity, physical activity, weight gain, and the development of knee OA after knee injury. The central hypothesis is that reductions in sports activity after knee injury contribute to weight gain, which subsequently increases the risk of inactivity and incident knee OA in the long-term. This proposal capitalizes on an on-going longitudinal study of clinical and functional outcomes in individuals after knee injury, specifically anterior cruciate injury and reconstruction (n=150). Outcome data were collected at baseline (soon after injury), and at the 6-month, 1-year, 2-year, 5-year follow-ups. 10-year follow-up data collection is on-going. Aim 1 will determine the trajectories of sports activity from 1 to 5 years after knee injury and the association of these trajectories with physical activity at 10-years. Aim 2 will investigate changes in body weight immediately (baseline to 6 months) and in the short-term (1 to 5 years) after knee injury, and how weight change relates to sports activity. Aim 3 will estimate the association of sports activity and weight status with incident knee OA after knee injury. The results of this proposal will provide a critical understanding of potential health consequences related to inactivity after injury, and serve as impetus to develop a long-term strategy to maintain knee health after injury through physical activity and healthy weight, which is not the focus of current post-injury intervention. By completing this fellowship under the guidance of experienced mentors in a strong environment, the applicant will be prepared to launch a career as an independent scientist investigating consequences of musculoskeletal injury.