Physical Activity Lifestyle Intervention for Emerging Adults with Congenital Heart Disease

项目总结/摘要 Jamie L.杰克逊，博士，是在生物行为健康中心在全国助理教授 儿童医院和俄亥俄州州立大学。她的职业目标是成为一名独立的临床科学家 在开发和实施随机行为临床试验，以提高自我， 先天性心脏病（CHD）的过渡年龄幸存者的管理。杰克逊医生接受了K23 该奖项旨在研究身体活动（PA）干预的可行性和初步疗效，以增加 CHD青少年中中度至重度PA参与。随着CHD幸存者进入成年期，他们 有更大的风险发展获得性心血管并发症，如高血压，冠状动脉 动脉疾病和心力衰竭这些合并症易受生活方式改变的影响，例如增加 宾夕法尼亚州在美国，新出现的成人CHD患者中PA的发生率相对未知，但一般情况下， 在成年期出现的人口下降。因此，为了成功地进行获得性肺炎的一级预防， 在这个不断增长的老年CHD幸存者人群中，无论是青少年还是 成年初显期可能是健康行为干预的最佳发展阶段。给定 成年初显期是一个独特的发展阶段，PA干预的可行性不可能是 假设，必须根据经验确定。为NHLBI K接受者提议的小额赠款计划 (R03)旨在1）评估作为杰克逊博士的一部分进行的相同PA干预的可行性 K23奖在新兴的成年CHD幸存者和2）获得参与者的定性反馈， 干预会议的内容和使用焦点小组的研究程序。与会者将包括30名 将随机分配至2个治疗组之一的患有危重CHD的新兴成人（19-25岁）：20周 视频会议管理的PA干预组（8，30分钟会话;跟踪活动并设定目标 使用Fitbit®）或接受Fitbit但不与研究干预人员接触的对照组。的 计划行为理论支持干预内容，如态度，规范信念， 将讨论感知行为控制。将邀请随机分配至干预组的受试者 参加一个焦点小组，提供进一步的反馈。客观和自我报告的可行性措施将 收集，包括招募率、干预会话依从性、留存率、评估 完成率和自我报告的干预经验。定性反馈将被录音， 转录并编码除了有助于杰克逊博士作为临床科学家的独立性， 目前的研究结果预计将提高竞争力，并为程序提供信息， 更大规模的R 01研究，将确定这种干预措施的疗效和长期效果， 过渡年龄CHD幸存者。

PROJECT SUMMARY/ABSTRACT Jamie L. Jackson, PhD, is an Assistant Professor in the Center for Biobehavioral Health at Nationwide Children’s Hospital and Ohio State University. Her career goal is to become an independent clinician-scientist with expertise in developing and implementing randomized behavioral clinical trials to improve self- management among transition-aged survivors of congenital heart disease (CHD). Dr. Jackson received a K23 award to examine the feasibility and preliminary efficacy of a physical activity (PA) intervention to increase moderate to vigorous PA engagement among adolescents with CHD. As CHD survivors enter adulthood, they have a greater risk for developing acquired cardiovascular complications, such as hypertension, coronary artery disease, and heart failure. These comorbidities are amenable to lifestyle changes, such as increasing PA. Rates of PA among emerging adults with CHD in the U.S. are relatively unknown, but rates in the general population decline during emerging adulthood. Therefore, for successful primary prevention of acquired cardiovascular complications in this growing population of aging CHD survivors, both adolescence and emerging adulthood may be optimal developmental stages to target for health behavior interventions. Given that emerging adulthood is a unique developmental stage, the feasibility of a PA intervention cannot be assumed and must be empirically determined. The proposed Small Grant Program for NHLBI K Recipients (R03) aims to 1) evaluate the feasibility of the same PA intervention being conducted as part of Dr. Jackson’s K23 award among emerging adult CHD survivors and 2) obtain qualitative feedback from participants on the content of the intervention sessions and study procedures using focus groups. Participants will include 30 emerging adults (ages 19-25) with critical CHD who will be randomized to 1 of 2 arms: a 20-week videoconferencing-administered PA intervention arm (8, 30 min sessions; tracking activity and setting goals using Fitbit®) or a comparison arm that receives a Fitbit, but has no contact with a study interventionist. The Theory of Planned Behavior underpins the intervention content such that attitudes, normative beliefs, and perceived behavioral control will be addressed. Participants randomized to the intervention arm will be invited to participate in a focus group to provide further feedback. Objective and self-report measures of feasibility will be collected, including recruitment rate, adherence to intervention sessions, retention rate, assessment completion rate, and self-report of the intervention experience. Qualitative feedback will be audio recorded, transcribed, and coded. In addition to contributing to Dr. Jackson’s independence as a clinician-scientist, the results of the current study are expected to enhance the competitiveness of and inform the procedures for a larger R01 study, which will establish efficacy and determine the long-term effects of this intervention among transition-aged CHD survivors.