Pharmacology and Nutritional Sciences: Multidisciplinary Approaches for Metabolic Disease

 描述(由申请者提供)：这是一项竞争性的培训计划续签，该计划最初是在1999年资助的。自成立以来，该培训计划的主要目标一直是为有前途的博士后学生在营养科学领域的成功职业生涯做准备，重点是营养作为代谢性疾病(肥胖症、糖尿病)、癌症、神经退行性疾病和心血管疾病的调节因素。在这次更新中，我们利用我们最近合并的药理学和营养科学系的独特学术结构，提供一个多学科计划，对研究生进行培训，以开发预防和治疗慢性病的营养和/或药理学方法。随着美国代谢性疾病发病率的增加，以及人们越来越多地认识到代谢性疾病是癌症、神经退行性疾病和心血管疾病等慢性疾病的基础，对能够在这一领域进行多学科研究的训练有素的科学家的需求变得至关重要。我们设想，通过这一多学科计划接受营养学和药理学交叉培训的科学家将拥有必要的技能，以应对这些常见但复杂的疾病过程。29名培训教师将围绕4个主题领域(肥胖/糖尿病、心血管疾病、癌症、神经科学/老龄化)提供培训，他们经常使用营养学和/或药理学方法来了解疾病的代谢基础。代谢性疾病多学科方法培训方案的目标是通过津贴和个人发展计划为有才华和多样化的研究生群体提供支持，为他们在代谢性疾病领域的生物医学职业生涯做好准备；提供创新的多学科教育，以促进使用以营养和药理学为基础的方法进行杰出研究的基本技能；提供一支成熟和多产的核心研究人员队伍，他们将作为受训者的导师和榜样；为受训者提供一个基础广泛但有凝聚力的研究环境，从而促进进一步的跨学科研究；以及提供高质量研究道德方面的培训。

 DESCRIPTION (provided by applicant): This is a competing renewal of a training program that was initially funded in 1999. Since its inception, the primary goal of this training program has been to prepare promising pre-doctoral students for successful careers in nutritional sciences, with a focus on nutrition as a modulator of metabolic disease (obesity, diabetes), cancer, neurodegenerative disease, and cardiovascular disease. In this renewal we capitalize upon our unique academic structure of a recently merged Department of Pharmacology and Nutritional Sciences to provide a multi-disciplinary program where graduate students are trained to develop nutritional and/or pharmacologic approaches towards the prevention and treatment of chronic diseases. The need for highly trained scientists capable of conducting multidisciplinary research in this area has become critical with the increased prevalence of metabolic diseases in the U.S., and the growing recognition that metabolic disorders underlie chronic diseases including cancer, neurodegenerative disease, and cardiovascular disease. We envision that scientists who receive cross-training in nutrition and pharmacology through this multidisciplinary program will have the necessary skill set to tackle these common yet complex disease processes. Twenty-nine training faculty who routinely employ nutritional and/or pharmacologic approaches to understand the metabolic basis of disease will provide training around 4 theme areas (obesity/diabetes, cardiovascular disease, cancer, neuroscience/aging). The goals of the Multidisciplinary Approaches for Metabolic Diseases Training Program are to provide support to a talented and diverse population of graduate students through stipends and individual development plans (IDPs) to prepare them for biomedical careers in the area of metabolic diseases; to provide innovative, multidisciplinary education to promote the essential skills for conducting outstanding research using nutrition and pharmacology-based approaches; to provide a core faculty of established and productive researchers who will serve as mentors and role models for the trainees; to provide a broad-based yet cohesive research environment for trainees, thus fostering further interdisciplinary research; and to provide training in the ethcal conduct of high quality research.