Biostatistics/Bioinformatics Core (BBC)

摘要：生物统计和生物信息学核心(BBC)的目标是与 转译病毒肿瘤学(CTVO)调查人员和其他核心科学家以提高 调查人员在拟议的CTVO中进行的研究。核心人员已选定 因为他们在生物统计学和生物信息学的相关领域具有专门知识，这是 CTVO项目，并促进基础研究和翻译研究方面的团队合作。核心将在以下方面提供支持 研究的所有阶段，从研究问题的表述、实验设计、数据开始 收集、分析和解释，以及撰写报告和传播成果。会是 从这项提案中可以明显看出，核心人员在规划和数据分析方面发挥了重要作用 为拟议中的实验。合作的确切性质将取决于科学细节和 该项目需要。除了对项目和其他核心的直接支持外，高级统计员和 生物信息学家还将专注于开发与以下方面有关的统计方法和生物信息学工具 CTVO中项目的需求。为实现这一目标，我们将承担以下具体目标：1. 为临床、实验室和基因组实验的设计提供生物统计学和生物信息学专业知识 2：提供关于数据的生物统计和生物信息学支持 管理、分析、可视化、整合和解释拟议的CTVO产生的数据 项目；和3：开展翻译生物统计学和生物信息学研究，以开发方法学工具 解决现有方法无法解决的任何问题。最终目标是提供 定制和创新的生物统计和生物信息学支持，以成功执行和完成 在此CTVO拨款申请中提出的项目。

Abstract: The goal of the Biostatistics and Bioinformatics Core (BBC) is to collaborate with Center for Translational Viral Oncology (CTVO) investigators and other core scientists to enhance the quality of the research undertaken by the investigators in the proposed CTVO. The Core personnel have been selected because of their expertise in relevant areas of Biostatistics and Bioinformatics that is specifically required for the CTVO projects and to foster team work in basic and translational research. The Core will provide support in all stages of the research, beginning with the formulation of the research questions, experimental design, data collection, analysis and interpretation, as well as writing of reports and dissemination of results. It will be apparent from this proposal that Core personnel have played a significant role in planning and data analyses for the proposed experiments. The exact nature of the collaboration will depend on the science specifics and the project needs. In addition to direct support of the projects and other Cores, senior statisticians and bioinformaticians will also focus on the development of statistical methods and bioinformatics tools related to the needs of the projects in the CTVO. To achieve this goal we will undertake the following specific Aims: 1: Provide biostatistics and bioinformatics expertise for the design of clinical, laboratory and genomic experiments and execution of the proposed CTVO projects; 2: Provide biostatistics and bioinformatics support on data management, analysis, visualization, integration and interpretation of data generated by the proposed CTVO projects; and 3: Undertake translational biostatistics and bioinformatics research to develop methodology tools to address any issues that could not be addressed by existing methods. The ultimate goal is to provide custom-made and innovative biostatistics and bioinformatics support to successfully execute and complete the projects proposed in this CTVO grant application.