SYSTEMS GENETICS AND GENOMICS OF LUNG DISEASES

描述(申请人提供)：本培训计划是目前由NHLBI K12 HL089990(“呼吸道疾病的翻译遗传学和基因组学”)资助的计划的扩展。这个K12项目已经成功运营了5年，与我们连续运营37年的T32 HL007427项目(《肺病临床流行病学》)紧密相连。这两个培训计划都侧重于慢性呼吸系统疾病的系统遗传学和基因组学，特别是哮喘和慢性阻塞性肺疾病(COPD)，这两个问题是主要的公共卫生问题。哮喘和COPD通过共同的环境和遗传易感性联系在一起；这些因素影响一生中疾病的表现。基于我们目前对复杂疾病的了解，迫切需要接受系统和综合基因组方法应用培训的个人进行呼吸道生物学的定量研究。因此，我们建议修改和扩展我们目前的K12培训计划，更加重视系统生物学、网络科学和多重组学方法。拟议中的K12计划将通过成功培训独立研究人员，帮助满足呼吸系统疾病研究中对计算生物学专业知识的需求，这些独立研究人员将继续领导他们在美国各地的研究计划。拟议的K12计划提供六个主要领域的研究培训：(1)系统遗传学(GWAS、精细作图和药物遗传学)；(2)功能遗传学；(3)新兴全基因组学(蛋白质组学/代谢组学/微生物学)；(4)转录学，包括整合基因组学；(5)表观基因组学；(6)系统生物学/网络建模。在这项建议中，要求提供两个学者名额。学者们与六个相互关联的研究领域的31名核心教师导师进行互动。每位奖学金获得者将有机会参与正在进行的联邦和非联邦资助研究项目的设计、执行和分析，并发展独立的职业道路。学者们的研究在钱宁网络医学部进行，这是布里格姆妇女医院(BWH)和哈佛医学院(HMS)医学部的一个研究部门。在完成我们的计划后，K12学者将有资格担任系统遗传学和基因组学方面的教职。学者们受益于与哈佛大学公共卫生学院生物统计系、波士顿儿童医院生物信息学项目和个性化遗传医学合作伙伴中心的密切关系。在过去的5年里，我们有100%的K12实习生保留在教职岗位上，62%的人已经转向完全独立的资助。

DESCRIPTION (provided by applicant): This training program is an extension of a program currently funded by NHLBI K12 HL089990 ("Translational Genetics and Genomics of Airways Diseases"). This K12 program, which has operated successfully for the past 5 years, is closely linked with our T32 HL007427 program ("Clinical Epidemiology of Lung Diseases"), which has been in continuous operation for 37 years. Both of these training programs focus on systems genetics and genomics of chronic respiratory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD), which are major public health problems. Asthma and COPD are linked via common environmental and genetic susceptibility; these factors influence disease expression throughout life. Based on our current knowledge of complex diseases, there is a critical need for individuals trained in the application of systems and integrative genomic methods to perform quantitative research in respiratory biology. Therefore, we propose to revise and extend our current K12 training program with an increased emphasis on systems biology, network science, and multiple -omics approaches. The proposed K12 program will be instrumental in meeting the need for increased computational biology expertise in respiratory disease research by successfully training independent research investigators who will go on to lead their own research programs across the U.S.. The proposed K12 program provides research training in six major areas: (1) Systems Genetics (GWAS, Fine Mapping, and Pharmacogenetics); (2) Functional Genetics; (3) Emerging -Omics (Proteomics/Metabolomics/Microbiomics); (4) Transcriptomics, including integrative genomics; (5) Epigenomics; and (6) Systems Biology/Network Modeling. Two Scholar slots are requested in this proposal. The Scholars interact with a pool of 31 core faculty mentors in the six interrelated research areas. Each Scholar will have the opportunity to become involved in the design, execution, and analysis of ongoing federally and non-federally funded research projects, as well as develop an independent career path. Scholars' research is conducted in the Channing Division of Network Medicine, a research division of the Department of Medicine at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS). After completing our program, K12 Scholars will be eligible to assume faculty positions in systems genetics and genomics. Scholars benefit from a close relationship with the Departments of Biostatistics at the Harvard School of Public Health, the Program in Bioinformatics at Children's Hospital Boston and the Partners Center for Personalized Genetic Medicine. In the past 5 years, we have had 100% retention of K12 trainees in faculty positions and 62 % who have moved on to completely independent funding.