Research Methods Core

研究方法核心提要 本土酒精研究和教育中心(NCARE)研究方法核心致力于 优化美洲印第安人和阿拉斯加原住民酒精使用障碍研究(AI/AN)。成功 酒精干预研究要求设计有可衡量、可实现的目标；充足的资金和 有效的资源分配；文化上适当的执行；以及定期评价。在本地 社区，这样的工作需要丰富的证据基础，了解最先进的科学知识，并植根于 AI/AN人员的日常体验和文化。这个核心的目标是最大限度地有效利用学习 通过标准化所有3个研究项目的测量和数据分析来提供资源；优化内部 和外部研究的有效性；以及为了确保推论分析对医疗保健提供者的相关性， 政策制定者、社区领袖和其他利益相关者致力于改善与AUD相关的差异 AI/ANS。核心成员将在以下各方面与首席调查员和研究团队密切合作 研究设计、样本选择、测量、数据收集、数据分析和研究结果的传播。我们的 跨学科方法综合了流行病学和因果推理理论的各种方法， 生物统计学、医学、临床试验、卫生服务、政策和卫生经济学。我们加强了这方面的专业知识 在定性方法方面有非凡的经验。我们的具体目标是：1)应用最先进的研究 设计和抽样策略来研究人工智能/ANS中的AUD差异。这项工作包括确保 所有研究措施的可靠性和有效性，有效利用NCARE资源使操作自动化， 设计有效的问卷和数据收集方法，管理数据，进行统计分析， 将定性和定量方法结合起来，为向科学和公众传播数据做好准备 受众；2)向试点项目资金接受者提供研究方法方面的支持和指导，并 NCARE研究员，后者的研究是在结构化的职业发展方案内进行的；以及 3)对建议的研究项目进行系统的卫生经济学评估，重点是短期- 与酒精使用障碍相关的健康干预的长期成本效益。这一核心将最大化 科学严谨，同时适应现实世界中出现的后勤和方法挑战 研究工作。我们经验丰富的团队可以提供最简单的分析来回答每一个问题 研究项目的科学问题，但它也可以适当地应用复杂的设计和分析工具， 并将通过不同程度的量化培训向观众传达结果。我们的分析师补充 他们的方法专长，对卫生研究的独特需求和挑战有深刻的理解 和原住民社区。

RESEARCH METHODS CORE ABSTRACT The Native Center for Alcohol Research and Education (NCARE) Research Methods Core is devoted to optimizing alcohol use disorder research in American Indian and Alaska Native populations (AI/AN). Successful alcohol intervention studies require designs with measurable, achievable objectives; adequate funding and efficient resource allocation; culturally appropriate implementation; and regular evaluation. In Native communities, such work requires a rich evidence base informed by state-of-the-art science and grounded in the day-to-day experience and culture of AI/AN people. The goals of this Core are to maximize efficient use of study resources by standardizing measurement and data analysis across all 3 Research Projects; to optimize internal and external study validity; and to ensure the relevance of inferential analyses for healthcare providers, policymakers, community leaders, and other stakeholders working to ameliorate AUD-related disparities for AI/ANs. Core members will work closely with the Principal Investigator and research teams on all aspects of study design, sample selection, measurement, data collection, data analysis, and dissemination of findings. Our transdisciplinary approach integrates diverse methods from epidemiology and causal inference theory, biostatistics, medicine, clinical trials, health services, policy, and health economics. We augment this expertise with exceptional experience in qualitative methods. Our Specific Aims are to: 1) Apply state-of-the-art research designs and sampling strategies to the study of AUD disparities in AI/ANs. This work includes ensuring the reliability and validity of all study measures, efficiently using NCARE resources to manualize operations, designing effective questionnaires and data collection methods, managing data, conducting statistical analyses, integrating qualitative and quantitative methods, and preparing data for dissemination to scientific and lay audiences; 2) Provide support and mentoring in research methods to recipients of Pilot Project funding and to NCARE Fellows, with the latter group’s research occurring within a structured career development program; and 3) Perform systematic health economics evaluations of the proposed Research Projects, focusing on the short- and long-term cost-effectiveness of alcohol use disorder-related health interventions. This Core will maximize scientific rigor while accommodating the logistical and methodological challenges that arise in real-world research endeavors. Our experienced team can facilitate the simplest possible analysis to answer each Research Project’s scientific questions, but it can also apply complex designs and analytic tools as appropriate, and will communicate results to audiences with varying levels of quantitative training. Our analysts complement their methodological expertise with a deep understanding of the unique needs and challenges of health research with Native communities.