Surgery Core

项目摘要/摘要 外科核心(核心B)将继续作为中央设施加强整个方案 为该计划的三个项目中的每个项目进行小鼠肾脏移植。此资源将允许 集中显微外科专业知识和努力，标准化手术入路，最大限度地减少手术 在移植方面造成差异，并在所有三个项目中照顾移植接受者，并更加协调一致地努力 在该计划的每个项目中，将详细介绍实验的设计和性能。具体的 核心B的任务将是：a)提供肾移植，必要时提供自体肾切除术 供方案个别项目的调查人员使用；b)监测肾移植的健康状况 受试者和检测肾功能障碍的证据；以及，c)协助研究人员进行实验 在该计划的项目中提出的治疗。

Project Summary / Abstract The Surgery Core (Core B) will continue to strengthen the overall program by serving as a central facility performing mouse kidney transplants for each of the three projects of the program. This resource will allow concentration of microsurgical expertise and effort, standardization of surgical approaches, minimize surgically imposed disparities in the grafts, and care for graft recipients in all three projects, and more concerted effort to be expended on the design and performance of experiments within each project of the program. The specific tasks of Core B will be to: a) To provide renal transplants and when necessary native kidney nephrectomies for investigators in the individual projects of the program; b) to monitor the health of the renal transplant recipients and test for evidence of renal dysfunction; and, c) to assist investigators with the experimental treatments proposed in the projects of the program.