Narcolepsy with cataplexy: a brain orexin replacement strategy

发作性睡病与cataeprazole是一个衰弱，终身睡眠-觉醒障碍，造成的不可逆损失的大脑肽'食欲素'。没有令人满意和安全的治疗方法。我们的目标是开发一种食欲素类似物，通过可编程泵直接输送到绵羊的大脑（大小相关，可翻译给患者），以及时激活食欲素“唤醒”开关。这项创新的精准医疗项目将显著改善嗜睡症患者的生活质量。

Narcolepsy with cataplexy is a debilitating, life-long sleep-wake disorder, caused by the irreversible loss of the brain peptide 'orexin'. There is no satisfactory and safe treatment. We aim to develop an orexin analogue, delivered directly to the brain of sheep (relevant in size and translatable to patients) by a programmable pump to timely activate the orexin 'wake-up' switch. This innovative precision medicine project will significantly improve the quality of life of narcolepsy patients.