Chemical Synthesis Core C

核心C化学合成 核心领导人：阿德里安·明纳德 摘要 化学合成核心C以下列方式支持化学发现和基准实验 不能通过分析天然细菌产品来实现。而致病物质中的天然化合物 分枝杆菌一般仅限于微克产量，化学合成可以提供许多毫克 耐用地提供大规模实验。而天然产物通常表现出许多近乎共洗脱的 分子变体，合成可以产生单一的纯化合物，用于标杆天然化合物和 作为严格确认新发现的化学结构的标准。含氮类似物的合成 定义的化学变化支持结构-活性关系的确定。核心C位于 格罗宁根大学Stratingh研究所，世界领先的实验室合成化学中心 专门研究化学合成的对映催化方法。因此，核心C具有独特的 具有定义复杂支链的多个手性中心的细菌代谢物生产方面的专业知识 结构，如邻苯二甲酸甘油酯、磺基糖脂、霉菌酸、酚糖脂等 脂类。核心C将产生毫克量的分枝杆菌代谢物，以支持项目1和项目3。 此外，核心将提供现有的和新的化合物，以产生一套全面的 分枝杆菌脂类在剖析和测绘B芯中的基准标准。

Core C Chemical Synthesis Core Leader: Adriaan Minnaard ABSTRACT The Chemical Synthesis Core C supports chemical discovery and benchmarking experiments in ways that cannot be achieved by analysis natural bacterial products. Whereas natural compounds from pathogenic mycobacteria are generally limited to microgram yields, chemical synthesis can provide many milligrams to durably supply large-scale experiments. Whereas natural products typically show many nearly co-eluting molecular variants, synthesis can produce a single pure compound for benchmarking natural compounds and as a standard for rigorously confirming newly discovered chemical structures. Synthesis of analogs with defined chemical variations supports determination of structure-activity relationships. Core C is housed at the Stratingh Institute at the University of Groningen, a world leading center for synthetic chemistry in a laboratory that specializes in enantiospecific catalytic methods of chemical synthesis. Thus, Core C has a unique expertise in production of bacterial metabolites with multiple chiral centers that define complex branched chain structures, such as phthiocerol dimycocerosate, sulfoglycolipids, mycolic acid, phenolic glycolipid and other lipids. Core C will produce milligram quantities of mycobacterial metabolites to support Projects 1 and 3. In addition, the Core will provide both existing and new compounds to generate a comprehensive set of standards for benchmarking mycobacterial lipids in the Profiling and Mapping Core B.