H2A Clinical Core

肝细胞癌（HCC）是一种非常常见和致命的癌症在非洲，并与艾滋病毒感染者的生活 时间越长，HCC的负担可能会增加。在先前的研究中，我们的团队确定了慢性B型肝炎感染 C病毒（HBV、HCV）、HIV和曼氏血吸虫是HCC的独立危险因素。相比 对于美国，撒哈拉以南非洲的HCC发生在更年轻和更晚期的阶段， 个月建议在马凯雷雷大学的同事之间建立东非和西非伙伴关系， 乌干达、塞内加尔的法恩大学和约翰霍普金斯大学专注于艾滋病毒和肝细胞癌 非洲的肝癌（HCC）：H2A联盟。建立在长期的合作研究，指导 在这两个国家的临床活动，我们的总体目标是减少肝癌的沉重负担， 撒哈拉非洲。我们提倡使用适当的药物治疗来研究癌症拦截策略 以中断或逆转这些导致HCC的感染的影响。我们将通过以下方式实现这一目标： 发展地方能力和进行重要的研究。该财团代表了一个复杂的 代表东西方的4个国家的研究者、工作人员、医院和大学之间的伙伴关系 非洲、瑞士和美国，6个临床研究中心，4个主要实验室，约20名合作研究者 英语和法语。临床和数据质量核心（CDQ）旨在支持标准化的 严格的数据收集、管理和分析联盟数据。CDQ将确保高质量的数据 严格收集，临床测量和实验室测试的评估应标准化 在研究中心之间，有效地进行数据协调，并提供高质量的分析数据集， 及时制作。CDQ核心通过以下方式为项目和试点项目提供支持： 发展核心。对科学和能力发展目标的支持可确保 联合体项目中全面、系统和严格的数据收集、管理和分析将 适当地最大限度地利用资源，并有很高的科学影响的可能性。

Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni as independent risk factors for HCC. Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with survival of only months. Proposed is an East and West African partnership between colleagues at Makerere University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden of HCC in sub- Saharan Africa. We advocate investigating cancer interception strategies using appropriate medical treatments to interrupt or reverse the impact of these HCC-causing infections. We will accomplish this objective by developing local capacity and performing important research. The Consortium represents a complex partnership between investigators, staff, hospitals, and universities in 4 countries representing East and West Africa, Switzerland and USA, with 6 clinical sites, 4 primary laboratories, and ~20 coinvestigators speaking English and French. The Clinical and Data Quality Core (CDQ) is designed to support the standardized rigorous data collection, management and analysis of Consortium data. CDQ will ensure that high quality data is rigorously collected, that assessment of clinical measurements and laboratory testing be standardized between sites, that data harmonization be effectively performed, and that high quality analytical datasets be produced in a timely manner. CDQ Core provides support for both Projects and to pilot projects through the Developmental Core. Support to both the scientific and capacity development objectives ensures that comprehensive, systematic and rigorous data collection, management and analysis in Consortium projects will appropriately maximize resources and have a high likelihood of scientific impact.