Bioassay Facility Core

摘要-生物测定因子核心 EaRTH中心生物测定设施核心将提供所需的技术和专业知识， 在UCSF EaRTH中心研究社区推进跨学科的环境研究。的 EaRTH中心生物测定设施核心将提供几个设施，以覆盖EaRTH中心的大部分 研究人员需要：1）广泛的生物监测设施，在许多领域提供化学检测和测量 不同的介质，包括空气、水、土壤、危险废物流、消费品和生物或人类 2）用于评估化学物质的SWATH质谱法以及传统蛋白质组学的最新技术水平 对生物过程的影响; 3）获得广泛的化学图书馆，并具有执行高 在模型生物体和组织培养物中的体内化学筛选通量; 4）人的新异种移植 组织植入小鼠体内，以更真实地模拟化学暴露。因此，核心将使EaRTH中心 研究人员通过提供高通量，高效率和低成本的环境研究， 有效的化学评价技术。

ABSTRACT - BIOASSAY FACILITY CORE The EaRTH Center Bioassay Facility Core will provide the enabling technology and expertise needed to advance cross-disciplinary environmental studies across the UCSF EaRTH Center research community. The EaRTH Center Bioassay Facility Core will offer several facilities to cover the majority of the EaRTH Center researchers needs: 1) an extensive biomonitoring facility providing chemical detection and measurement in many different media including air, water, soil, hazardous waste streams, consumer products and biological or human tissues; 2) state of the art SWATH mass spectrometry as well as traditional proteomics for assessing a chemical's effect on biological processes; 3) access to an extensive chemical library combined with ability to perform high- throughput in vivo chemical screening in a model organism and tissue culture; 4) novel xenografting of human tissue into mice to more realistically model chemical exposures. The Core therefore will enable EaRTH Center researchers to push the boundaries of environmental research by providing high-throughput, efficient and cost- effective chemical evaluation technologies.