Identifying interconnections of the disparities in childhood obesity

项目摘要/摘要： 儿童肥胖症是一个严重的问题，特别是在低识字率和低收入人群中。 少数族裔儿童。肥胖儿童患2型糖尿病、心血管疾病、癌症、 哮喘和更严重的冠状病毒疾病2019年(新冠肺炎)结果。大约36%的儿童生活在贫困中， 42%的人生活在低收入家庭。在家长教育方面也存在种族和民族差异。40.4%的 非西班牙裔白人儿童的父母受过大学教育，而非西班牙裔黑人儿童的这一比例为20.3%。这个 非洲裔美国人的肥胖率为24.2%，白人为16.1%。非裔美国成年人被发现 比高加索人有更高的氧化压力。几种挥发性有机化合物(VOC)是由 活性氧物种。然而，在直接考察两者之间的联系的研究中，存在着显著的差距 氧化应激和挥发性有机化合物的种族差异。 这项研究的总体目标是确定尿液氧化应激、挥发性 有机化合物概况和氧化应激衍生的VOC代谢物与种族/民族和童年 肥胖。我们计划通过实现以下具体目标来实现此应用程序的目标。(1) 测定尿中氧化应激、VOC代谢物和氧化应激衍生的VOCs 儿童肥胖症的种族/民族差异。(2)确定氧化应激是否诱导VOC的释放 代谢物。 这项研究将从根本上促进我们对氧化应激之间的联系的理解 和挥发性有机化合物代谢物在儿童肥胖方面的差异。这些发现将对我们有所帮助 揭示儿童肥胖差异的早期代谢非侵入性生物标志物。我们坚信 参与该项目的本科生和研究生所获得的直接研究经验将 帮助他们了解与儿童肥胖差异相关的病理生理学。成功者 研究的完成将帮助参与研究的学生深入了解差异并为 未来的科学家将在与健康相关的学科中追求自己的职业生涯。

PROJECT SUMMARY/ABSTRACT: Childhood obesity is a serious concern, particularly in low literacy and low-income populations among minority children. Obese children are at higher risk of developing type 2 diabetes, cardiovascular disease, cancer, asthma, and worse coronavirus disease 2019 (COVID-19) outcomes. Around 36% of children live in poverty, and 42% live in low-income families. There are also racial and ethnic disparities in parent education. 40.4% of non-Hispanic white children have a college-educated parent, compared with 20.3% of non-Hispanic black. The rate of obesity in African Americans is 24.2%, and in whites is at 16.1%. African American adults are found to have high oxidative stress than Caucasians. Several volatile organic compounds (VOCs) are generated by the reactive oxygen species. However, there is significant gap in the research directly examining the association of racial disparities with oxidative stress and VOCs. The overall objective of this study is to determine the association of urinary oxidative stress, volatile organic compounds profile, and oxidative stress-derived VOC metabolites with race/ethnicity and childhood obesity. We plan to accomplish the objective of this application by pursuing the following specific aims. (1) Determine the urinary oxidative stress, VOC metabolites, and oxidative stress-derived VOCs associated with race/ethnic disparity in childhood obesity. (2) Determine if oxidative stress induces the release of VOC metabolites. This research will fundamentally advance our understanding of the association between oxidative stress and the volatile organic compound metabolites with the disparities in childhood obesity. The findings will help reveal the early metabolic non-invasive biomarkers of disparities in childhood obesity. We strongly believe that the direct research experience gained by the undergraduate and graduate students working on this project will help them understand the pathophysiology associated with the disparities in childhood obesity. The successful completion of the study will help the involved students to gain in-depth knowledge of disparities and prepare future scientists to pursue their careers in health-related disciplines.