Collaborative Pediatric Critical Care Research Network - Clinical Site

项目概要/摘要-明尼苏达大学 协作儿科重症监护研究网络（CPCCRN）在建立 儿科重症监护医学知识基础。本网站建议的总体目标是为大学 明尼苏达共济会儿童医院（UMMCH），在研究中心主要研究者玛丽的领导下 Steiner，MD，MS，加入CPCCRN的扩展迭代。UMMCH是一个独立的四级护理， 位于明尼苏达州明尼阿波利斯市的学术儿童医院，为各种儿童和家庭提供服务 种族民族和社会经济背景它有一个24张病床的混合内科/外科和心脏儿科 重症监护病房，并提供全方位的儿科和外科专科服务。UMMCH有一个 强大的临床研究和创新的历史，结合大学的资源， 明尼苏达州的赠地大学。儿科重症监护研究包括许多已完成和 正在进行的研究由多个教师，包括该补助金的共同调查员倡导。随着增加 来自内部和外部赠款的支持以及儿科器械创新中心的发展， 该部门在2019年开展新研究方面排名第三，仅次于血液学/肿瘤学， HSCT。儿童明尼苏达州（儿童）将作为我们的附属网站的领导下，阿尔贝托 马里兰州金莺市儿童医院是一家非营利性的独立儿童医院，也位于明尼阿波利斯， 长期参与重症监护研究，包括几项CPCCRN研究。在一起， UMMCH和儿童医院将提供55张儿科ICU病床和超过3500名年度住院患者， 涵盖了整个上中西部的大多数重症儿童，并将促进参与 大型临床试验建议的“脓毒症诱导的多器官免疫调节的个性化” 功能障碍综合征（MODS）”试验解决了免疫抑制儿童将受益的假设 粒细胞巨噬细胞集落刺激因子的使用， 过度炎症将受益于靶向抗炎治疗。将根据以下方面评价获益： 从MODS中恢复，以及短期和长期健康相关的生活质量指标。这种伙伴关系 具备成功完成本试验的知识和技能，包括样本采集和处理， 免疫表型和收集短期和长期结果。斯坦纳博士和金莺队 支持其各自机构参与CPCCRN并优先考虑患者招募， 应计费用。各院校均致力与CPCCRN网站及数据中心合作， 协调中心进行拟议的和未来的研究。我们的临床中心和辅助中心将 为我们才华横溢的年轻教师提供当地的指导，并将支持他们参与中央 所需CPCCRN网络第B.3节中描述的CPCCRN指导活动 此PL 1应用程序的总体组件的组织结构附件。

PROJECT SUMMARY/ABSTRACT – University of Minnesota The Collaborative Pediatric Critical Care Research Network (CPCCRN) has been critical in building the knowledge base of pediatric critical care medicine. The overall aim of this site proposal is for the University of Minnesota Masonic Children's Hospital (UMMCH), under the leadership of Site Principal Investigator, Marie Steiner, MD, MS, to join this expanded iteration of CPCCRN. UMMCH is a free-standing, quaternary care, academic children’s hospital located in Minneapolis, MN, serving children and families across a diverse range of racial, ethnic, and socioeconomic backgrounds. It has a 24-bed mixed medical/surgical and cardiac pediatric intensive care unit and offers the full spectrum of pediatric and surgical subspecialty services. UMMCH has a strong history of clinical research and innovation in conjunction with the resources of the University of Minnesota, the state’s land grant university. Pediatric critical care research includes numerous completed and ongoing studies championed by multiple faculty, including the Co-Investigators for this grant. With increasing support from internal and external grants and the development of the Pediatric Device Innovation Center, the Division was third in the Department in launching new studies in 2019, behind Hematology/Oncology and HSCT. Children's Minnesota (Children’s) will serve as our Ancillary Site under the leadership of Alberto Orioles, MD. Children’s is a not-for-profit, freestanding children’s hospital also located in Minneapolis, with a long-standing history of participation in critical care research, including several CPCCRN studies. Together, UMMCH and Children's will provide access to 55 pediatric ICU beds and over 3500 annual admissions, which captures the majority of critically ill children throughout the Upper Midwest and will facilitate participation in large clinical trials. The proposed “Personalized Immunomodulation in Sepsis-Induced Multiple Organ Dysfunction Syndrome (MODS)” trial addresses the hypothesis that immunosuppressed children will benefit from administration of granulocyte macrophage-colony stimulating factor and that children with hyperinflammation will benefit from targeted anti-inflammatory therapy. Benefit will be evaluated in terms of recovery from MODS, as well as short- and long-term health-related quality of life measures. This partnership has the knowledge and skills to successfully complete this trial, including sample collection and processing for immunophenotyping and collection of short- and long-term outcomes. Drs. Steiner and Orioles have the full support of their respective institutions to participate in CPCCRN and to prioritize patient recruitment and accrual to its studies. The institutions are strongly committed to collaboration with CPCCRN sites and the Data Coordinating Center to conduct the proposed and future research. Our clinical center and ancillary site will provide local mentorship for our highly talented young faculty and will support their participation in the central CPCCRN mentoring activities that are described in Section B.3 of the required CPCCRN Network Organizational Structure attachment to the Overall Component of this PL1 application.