Proteogenomics Core

总结 对于COBRE II期，转化儿科研究中心（CTPR）将支持一项新的 蛋白质基因组学核心是必不可少的研究中心的使命。蛋白质组学核心是一个 独特的新核心，将提供与机构现有服务不重复的服务。 蛋白质组学是蛋白质组学与基因组学、转录组学相结合的产物。这个新的核心 将为中心成员提供有经验的人员进行非标准蛋白质组学，基因组学， 表观基因组应用，并获得高技能的生物信息学家的尖端数据分析， 一体化蛋白质基因组学核心将由Stephanie Byrum博士指导，他带来了丰富的 拥有成功领导核心设施的经验，并被国家公认为该领域的领导者。这个新 蛋白质基因组学核心将拥有最先进的蛋白质基因组学应用设备和工作人员， 复杂的数据集成策略。我们COBRE第二阶段的短期目标是提供所需的资源， 开发这个新的蛋白质基因组学核心，这将提供中心所需的基本研究服务 成员和其他研究人员。我们在第三阶段及以后的长期目标是定位这个新的核心 通过建立补给机制并作为未来计划的核心，实现长期可持续性 CTPR调查人员提交的项目赠款。对于这个建议，我们的目标是开发一个新的COBRE 蛋白基因组学核心，将提供高度专业化的蛋白基因组学支持和教育机会 当前和未来的COBRE研究项目负责人和其他中心成员。为了实现我们的目标， 我们将追求以下具体目标：（1）开发一个新的COBRE蛋白基因组学核心， 为COBRE研究项目负责人提供专业的非标准蛋白质基因组学数据收集和分析 和其他中心成员，以及（2）提供资源和教育研讨会，以支持COBRE研究 项目负责人和其他中心成员。

Summary For COBRE Phase II, the Center for Translational Pediatric Research (CTPR) will support a new Proteogenomics Core that is essential for the research mission of the center. The Proteogenomics Core is a unique, new core that will provide services that are not duplicative of those existing at the institution. Proteogenomics is defined as the integration of proteomics with genomics and transcriptomics. This new core will provide center members’ access to experienced personnel for non-standard proteomic, genomic, and epigenomic applications, and access to highly skilled bioinformaticians for cutting-edge data analysis and integration. The Proteogenomics Core will be directed by Dr. Stephanie Byrum, who brings a wealth of experience leading successful core facilities and who is nationally-recognized as a leader in the field. This new Proteogenomics Core will have state-of-the-art equipment for proteogenomics applications and staff for sophisticated data integration strategies. Our short-term goal for COBRE Phase II is to provide resources needed to develop this new Proteogenomics Core, which will provide essential research services needed for center members and other researchers. Our long-term goal during Phase III, and beyond, is to position this new core for long-term sustainability through establishing a recharge mechanism and serving as a core in future program project grants submitted by CTPR investigators. For this proposal, our objective is to develop a new COBRE Proteogenomics Core that will provide highly-specialized proteogenomics support and educational opportunities for current and future COBRE Research Project Leaders and other center members. To achieve our objective, we will pursue the following Specific Aims: (1) Develop a new COBRE Proteogenomics Core for highly- specialized, non-standard proteogenomics data collection and analysis for COBRE Research Project Leaders and other center members and (2) Provide resources and educational workshops to support COBRE Research Project Leaders and other center members.